geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Induced mutagenic effects in the nucleotide excision repair deficient Drosophila mutant mus201D1, expressing a truncated XPG protein


, : Induced mutagenic effects in the nucleotide excision repair deficient Drosophila mutant mus201D1, expressing a truncated XPG protein. Mutation Research 461(4): 279-288, 5 January

Defects in nucleotide excision repair (NER) as defined by the UV sensitivity of xeroderma pigmentosurn (XP), Cockayne syndrome (CS) and trichothiodystrophy (TTD) patients has lead to the identification of most of the genes involved: XPA through XPG, CSA and CSB. Whereas XP patients often show an increased risk for skin cancer after exposure to sunlight, this is not the case for patients with CS and TTD. Several CS patients have been shown to carry a defect in the XPG gene. The XPG, a structure specific endonuclease makes the incision 3' of damage and is also involved in the subsequent 5'incision during the NER process. In addition, XPG plays a role in the removal of oxidative DNA damage. The Drosophila XPG gene was isolated and based on the molecular defect of a spontaneous (insertion) and an EMS induced mutant, it was shown that a mutated XPG is responsible for the Drosophila mutagen-sensitive mutants mus201. One of these mutants, mus201D1 has been used extensively in studies of the effects and mechanisms of many chemical mutagens as well as X-rays. The results of these studies are discussed in the light of the finding that mus201p is the Drosophila homologue of XPG.

US$19.90

DOI: 10.1016/s0921-8777(00)00055-0


Other references

Cockerell, T.D.A., 1897: New insects from Embudo, New Mexico. Annals of Natural History, XX 510-514

Smith, D.E.; Andrews, J.S., 1957: The uptake of oxygen by flour dough. Flour doughs take up O2 during mixing. The amount of O2 consumed by patent flour doughs is small but with lower grade flours the amount is substantial. Removal of the lipids decreases the oxygen uptake but uptakes are restored by the addition of l...

The Livostin Study Group, 1993: A comparison of topical levocabastine and oral terfenadine in the treatment of allergic rhinoconjunctivitis. This study was undertaken to compare the efficacy of twice-daily levocabastine, a new topical H-1-blocking antihistamine, with that of twice-daily oral terfenadine in the treatment of allergic rhinoconjunctivitis. A total of 128 adult patients wit...

Kapoor, N., 2011: Expanding the definition of healing--cancer education in India. Enormous increases are predicted in the global burden of cancer, with the bulk of these cases is expected to occur in low- and middle-income countries like India. This paper outlines the existing scenario of cancer incidence and mortality, health...

Sun, Z-Ming.; Xia, S-Qing.; Huang, Y-Zhi.; Wu, L-Ming.; Mao, J-Gao., 2005: Ca6Cu2Sn7: novel 3D open framework with unusual Sn4 tetramers. The new ternary polar intermetallic phase, Ca6Cu2Sn7, has been synthesized by the solid-state reaction of the stoichiometric mixture of the pure elements in welded Ta tubes at high temperature. Its structure was established by single-crystal X-ray...

Schill, N.J.; Anderson, R.A., 2009: Two novel phosphatidylinositol-4-phosphate 5-kinase type Igamma splice variants expressed in human cells display distinctive cellular targeting. The generation of various phosphoinositide messenger molecules at distinct locations within the cell is mediated via the specific targeting of different isoforms and splice variants of phosphoinositide kinases. The lipid messenger PtdIns(4,5)P(2)...

Gao, D-Zhen.; Liu, G-Hua.; Song, H-Qun.; Wang, G-Lei.; Wang, C-Ren.; Zhu, X-Quan., 2016: The complete mitochondrial genome of Gasterophilus intestinalis, the first representative of the family Gasterophilidae. Gasterophilus spp. (Diptera: Gasterophilidae) has a worldwide distribution; however, no complete mitochondrial (mt) genome data is available for Diptera which has greatly impeded population genetics, phylogenetics, and systematics studies in Gaste...

Kowal, R.; Ebel, B., 1974: Insects attacking forest trees in the South. Alabama forest products: 17 (8) 167-173

Yu, H.Y.; Inoguchi, T.; Kakimoto, M.; Nakashima, N.; Imamura, M.; Hashimoto, T.; Umeda, F.; Nawata, H., 2001: Saturated non-esterified fatty acids stimulate de novo diacylglycerol synthesis and protein kinase c activity in cultured aortic smooth muscle cells. Aims/hypothesis: Insulin resistance is linked with a cluster of multiple risk factors and excessive acceleration of atherosclerosis. The underlying mechanism is not, however, fully understood. Methods: To determine the link between insulin resista...

Harty, J.C.; Farragher, B.; Boulton, H.; Kirwell, J.; Heelis, N.; Uttley, L.; Venning, M.C.; Gokal, R., 1993: Is the correlation between the normalised protein catabolic rate and KT/V the result of mathematical coupling?. Journal of the American Society of Nephrology 4(3): 407