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Inhibition of PKC and ERK1/2 in cultured rat vascular smooth muscle cells by angiotensin-(1-7)


, : Inhibition of PKC and ERK1/2 in cultured rat vascular smooth muscle cells by angiotensin-(1-7). Shengli Xuebao 53(5): 361-363

The present study was undertaken to investigate the effects of angiotensin-(1-7) (Ang-(1-7)) on the proliferation and expression of protein kinase C (PKC) and extracellular regulated protein kinases (ERK1/2) of vascular smooth muscle cells (VSMCs) by techniques of Western blot, 3H-thymidine (3H-TdR) and 3H-leucine (3H-Leu) incorporation. Ang II increased VSMC DNA and protein synthesis, and promoted protein expression of PKC-zeta and ERK1/2.

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