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Inhibition of angiotensin-converting enzyme by quercetin alters the vascular response to bradykinin and angiotensin I

, : Inhibition of angiotensin-converting enzyme by quercetin alters the vascular response to bradykinin and angiotensin I. Pharmacology (Basel) 65(4): 182-186, August

Quercetin, one of the most widely distributed flavonoids in the plant kingdom, inhibits various enzymes. This study examined its inhibitory effect on the angiotensin-converting enzyme activity through the cardiovascular response to bradykinin and angiotensin I. Quercetin pretreatment (88.7 mumol/kg p.o., 45 min; 14.7 mumol/kg i.v., 5 min) significantly potentiated the hypotensive effect of bradykinin (10 nmol/kg i.v.). This association was significantly attenuated by an antagonist of the B2 receptor. In addition, the hypertensive response to angiotensin I (0.1 nmol/kg i.v.) was significantly reduced by quercetin pretreatment using the same parameters as before. These results suggest an inhibitory effect of quercetin on the angiotensin-converting enzyme activity, similar to that of captopril. Quercetin was equally effective when given orally or intravenously.


PMID: 12174832

DOI: 10.1159/000064341

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Hashikawa, K.; Moriwaki, H.; Oku, N.; Handa, N.; Matsumoto, M.; Kimura, K., 1991: Basic and clinical characteristics of 99mTc-HMPAO SPECT. Nihon Rinsho. Japanese Journal of Clinical Medicine 49(7): 1480-1485

Wu, J., 2001: Nondiscrete functional pathways and asymmetric transitional zone: a new concept for AV nodal electrophysiology. Journal of Cardiovascular Electrophysiology 12(4): 487-488

Day, H.W., 2012: Normal functional occlusion; its importance in prevention and treatment of pyorrhea. Journal of the American Dental Association 33: 468-476

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Moriguchi E.H.; Tamachi H.; Nakaya N.; Goto Y., 1990: Differences in the response to pravastatin treatment between familial and non familial hypercholesterolemic patients. Journal of Drug Development 3(SUPPL 1): 265-270

Shek, P.N.; Chou, C.T.; Dubiski, S.; Cinader, B., 1976: Rabbit lymphoid cells part 1 thymus derived cell mitogens cell volume and adherence properties as probes for cellular heterogeneity. Thymus-derived [T] cell populations [rabbit] were characterized by sedimentation velocity in the Earth's gravitational field, by adherence properties and in terms of RTLA [rabbit thymus lymphoid antigen]. T cells responding to mitogens, were...

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Neurath A.R.; Kent S.B.H.; Strick N.; Offensperger W.; Wahl S.; Christman J.K.; Acs G., 1986: Synthetic peptides as reagents for detection of pre s specific hepatitis b antigens and antibodies. Peeters, H (Ed ) Protides Of The Biological Fluids Proceedings Of The Colloquium, 34; Brussels, Belgium, Xxix+936p Pergamon Press: Oxford, England; New York, N Y , Usa Illus 129-132

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