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Inhibition of human platelet adenylate cyclase activity by adrenaline, thrombin and collagen: analysis and reinterpretation of experimental data


, : Inhibition of human platelet adenylate cyclase activity by adrenaline, thrombin and collagen: analysis and reinterpretation of experimental data. Biochemical Journal 340: 245-253

Mathematical models based on the current understanding of stimulation and inhibition of adenylate cyclase (AC) activity have been developed and used to analyse experimental data (Farndale, Winkler, Martin and Barnes (1992) Biochem. J. 282, 25-32) describing the inhibition of human platelet AC by collagen, thrombin and adrenaline. Here it has been demonstrated that neither affinities of receptors specific for adrenaline or thrombin nor the activity of cAMP phosphodiesterase are affected by collagen. Both collagen and thrombin at high doses act as effective inhibitors of AC activity. Inhibition of AC activity by collagen proceeds via two parallel pathways; the same is true for thrombin at moderate concentrations, and the two ligands act independently. The G-protein-dependence of these pathways is distinct from that mediating inhibition of AC activity by adrenaline, i.e. Gi2. Convergence of the inhibitory pathways takes place at the catalytic subunit of AC.

US$19.90

PMID: 10391837

DOI: 10.1042/0264-6021:3400245


Other references

Mariani, M., 1957: The cultivation of hard wheats in northern Cyrenaica. Brief descriptive notes are included concerning 13 varieties, of which Bidi and Senatore Cappelli are the most popular.

Kosley, R.W.J.; Palermo, M.G.; Shimshock, S.J.; Wolf, V., 2002: Aminoalkylphenol derivatives and related compounds. Novel aminoalkylphenols, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction utilizing the aminoalkylphenols or compositions thereof are disclosed.

Yeo P.F., 1971: Cultivars of bergenia saxifragaceae in the british isles. Baileya 18(3): 96-112

Lee D.B.N., 1982: Unanticipated stimulation of active calcium absorption by gluco corticoids. Kidney International 21(1): 137

Moore, M.A.; Wander, R.C.; Xia, Y.M.; Du, S.H.; Butler, J.A.; Whanger, P.D., 2000: Selenium supplementation of Chinese women with habitually low selenium intake increases plasma selenium, plasma glutathione peroxidase activity, and milk selenium, but not milk glutathione peroxidase activity. Twenty-one pregnant women living in Xichang County, China, a selenium-deficient area, were divided into two groups and given either a placebo (n = 10) as yeast or selenium-enriched yeast tablets (n = 11) to provide 100 microg selenium per day. Thi...

Gerhartz, H., 1961: Principles in selectivity of cytostatic effects. Strahlentherapie Suppl 48: 126-135

Anonymous, 2013: The dependence of dark matter profiles on the stellar to halo mass ratio a prediction for cusps vs cores. We use 31 simulated galaxies from the MaGICC project to investigate theeffects of baryonic feedback on the density profiles of dark matter (DM)haloes. The sample covers a wide mass range: 9.4e9<Mhalo/Msun<7.8e11, hostinggalaxies with stellar...

Wang, T.; Zhou, H.; Xie, H.; Mu, Y.; Xu, Y.; Liu, J.; Zhang, X., 2014: Epigallocatechin-3-gallate inhibits TF and TNF-α expression induced by the anti-β2GPI/β2GPI complex in human THP-1 cells. Epigallocatechin-3-gallate (EGCG) is the major polyphenolic component of green tea. The aim of the current study was to investigate the inhibitory effects of EGCG on anti-β2-glycoprotein I (β2GPI)/β2GPI-induced tissue factor (TF) and tumor necr...

Tilby, S.E., 1994: Method and apparatus for separation of sugarcane pith from rind. Official Gazette of the United States Patent & Trademark Office Patents 1169(3): 1631-1632, Dec 20

Nolte, H.; Puente-Egido, J.J., 1969: The new local anesthetic bupivacaine (carbostesin) in clinical use. Der Anaesthesist 18(8): 264-265