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Interferon gamma derived from CD4(+) T cells is sufficient to mediate T helper cell type 1 development

, : Interferon gamma derived from CD4(+) T cells is sufficient to mediate T helper cell type 1 development. Journal of Experimental Medicine 188(9): 1651-1656

Interferon gamma (IFN-gamma) has been implicated in T helper type 1 (Th1) cell development through its ability to optimize interleukin 12 (IL-12) production from macrophages and IL-12 receptor expression on activated T cells. Various systems have suggested a role for IFN-gamma derived from the innate immune system, particularly natural killer (NK) cells, in mediating Th1 differentiation in vivo. We tested this requirement by reconstituting T cell and IFN-gamma doubly deficient mice with wild-type CD4(+) T cells and challenging the mice with pathogens that elicited either minimal or robust IL-12 in vivo (Leishmania major or Listeria monocytogenes, respectively). Th1 cells developed under both conditions, and this was unaffected by the presence or absence of IFN-gamma in non-T cells. Reconstitution with IFN-gamma-deficient CD4(+) T cells could not reestablish control over L. major, even in the presence of IFN-gamma from the NK compartment. These data demonstrate that activated T cells can maintain responsiveness to IL-12 through elaboration of endogenous IFN-gamma without requirement for an exogenous source of this cytokine.


PMID: 9802977

Other references

Dodin D.A.; Volod ko S.A.; Sukhov L.G.; Kostrov Y.V.; Ryabov V.V.; Samoylov A.G., 1990: Optimal strategy of geochemical exploration of ore deposits in closed regions; example from northern Krasnoyarsk. Pages 36-44 1990

Loewenthal, L.J.; Lurie, H.I., 1956: An outbreak of linear scarring alopecia. British Journal of Dermatology 68(3): 88-98

Beato, V.; Sendiña-Nadal, I.; Gerdes, I.; Engel, H., 2005: Noise-induced wave nucleations in an excitable chemical reaction. We study both experimentally and numerically the temporal coherence of noise-induced wave nucleations in excitable media subjected to external fluctuations with finite correlation time. The experiments are performed with the light-sensitive varian...

Entwisle, G.; Henderson, M., 1964: An Undergraduate Training Program In Epidemiology. Journal of Medical Education 39: 382-387

Yu, X.; Jia, R.; Huang, J.; Shu, B.; Zhu, D.; Liu, Q.; Gao, X.; Lin, M.; Yin, Z.; Wang, M.; Chen, S.; Wang, Y.; Chen, X.; Cheng, A., 2014: Attenuated Salmonella typhimurium delivering DNA vaccine encoding duck enteritis virus UL24 induced systemic and mucosal immune responses and conferred good protection against challenge. Orally delivered DNA vaccines against duck enteritis virus (DEV) were developed using live attenuated Salmonella typhimurium (SL7207) as a carrier and Escherichia coli heat labile enterotoxin B subunit (LTB) as a mucosal adjuvant. DNA vaccine plas...

Lucas, M.; Sanchez Margalet, V., 1995: Protein kinase C involvement in apoptosis. 1. Conflicting observations on the involvement of PKC in apoptosis point to a great variability depending on cell type, agent or condition causing apoptosis, phase of the cell cycle and intracellular signaling pathway. 2. Inhibition by PKC of stor...

Chafiki D.; Souhel A.; Canerot J.; Ibouh H.; E.H.riri K.; Taj Eddine K., 2001: The Liassic mud-mounds from central High Atlas (Morocco); stratigraphic and geodynamic settings. Geologie Mediterraneenne 28(1-2): 49-52

Harrison, K.A.; Lister, U.G., 1966: Successful pregnancy in a patient with adrenogenital syndrome. Journal of Obstetrics and Gynaecology of the British Commonwealth 73(3): 493-495

Conforto, A.B.; Santos, R.Laurenti.dos.; Farias, S.Nascimento.; Marie, S.Kazue.Nagahashi.; Mangini, N.; Cohen, L.G., 2008: Effects of somatosensory stimulation on the excitability of the unaffected hemisphere in chronic stroke patients. Somatosensory stimulation of the paretic upper limb enhances motor performance and excitability in the affected hemisphere, and increases activity in the unaffected hemisphere, in chronic stroke patients. We tested the hypothesis that somatosensor...

Duronio, Robert J., 2004: A breath of fresh air for cyclin D/Cdk4: Triggering growth via Hph. Activation of Cyclin D/Cdk4 stimulates progression through the G1-S phase of the cell cycle in many organisms. In Drosophila, Cyclin D/Cdk4 also induces cell growth independently of cell cycle progression. In this issue of Developmental Cell, Frei...