geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Isoflavones reduce arterial stiffness: a placebo-controlled study in men and postmenopausal women


, : Isoflavones reduce arterial stiffness: a placebo-controlled study in men and postmenopausal women. Arteriosclerosis, Thrombosis, and Vascular Biology 23(6): 1066-1071

Objective: This study was undertaken to address the vascular effects of isolated isoflavones as potential contributors to their cardioprotective properties, focusing on biochanin and formononetin. Methods and Results: In a randomized, double-blind trial, 80 healthy subjects, 46 men and 34 women, 45 to 75 years of age, received isoflavones enriched in either biochanin or formononetin (precursors of genistein and daidzein; 80 mg/d) crossed over randomly with placebo in two 6-week periods. The end points were measured at baseline and after each intervention and included large artery stiffness (systemic arterial compliance and pulse wave velocity), endothelial function in conduit arteries (flow-mediated vasodilation), 24-hour ambulatory blood pressure, and total peripheral resistance. Isoflavone intervention significantly reduced arterial stiffness with improved systemic arterial compliance (P=0.04; repeated-measures ANOVA, Bonferroni correction) attributable to a reduction in total peripheral resistance (P=0.03) and a corresponding reduction in central pulse wave velocity (P=0.02) compared with placebo. Isoflavones did not affect blood pressure (P=0.5) or flow-mediated vasodilation (P=0.44). Improvements seemed limited to formononetin-enriched isoflavones (adjusted P=0.06). Formononetin treatment also reduced circulating vascular adhesion cell molecule-1 (P<0.01). Conclusions: In normotensive men and postmenopausal women, red clover isoflavones enriched in formononetin reduced arterial stiffness and total vascular resistance but had no effect on blood pressure. These effects may partly explain the lower cardiovascular risk in populations eating isoflavone-rich diets.

US$19.90

PMID: 12714433

DOI: 10.1161/01.ATV.0000072967.97296.4A


Other references

Chirva V.Y.; Kintya P.K.; Cheban P.L., 1973: Tri terpene glycoside from gypsophila acutifolia. Chemistry of Natural Compounds (English Translation of Khimiya Prirodnykh Soedinenii) 6(4): 508

Saberi, N.; Patel, S.; Mannocci, F., 2016: Comparison of centring ability and transportation between four nickel titanium instrumentation techniques by micro-computed tomography (μCT). To compare the centring ability and transportation of ProTaper Next (PTN), ProTaper Universal (PTU), Race 123 and Revo S using micro computed tomography (μCT). Sixty mesial root canals of thirty mandibular molars were divided virtually into coron...

Ezuddin, S.H.; Sfakianakis, G., 2001: FDG-PET as a complementary study to angiography for decision making on revascularization in severe coronary artery disease. Journal of Nuclear Medicine 42(5 Supplement): 97P, May

Grayson, C.; Molday, R.S., 2005: Dominant negative mechanism underlies autosomal dominant Stargardt-like macular dystrophy linked to mutations in ELOVL4. ELOVL4 (elongation of very long chain fatty acids 4) is a member of the ELO family of proteins involved in the biosynthesis of very long chain fatty acids. Protein truncation mutations in ELOVL4 have been identified in patients with autosomal domi...

Seshadri, G.; Knudson-Martin, C., 2015: How couples manage interracial and intercultural differences: implications for clinical practice. This study focused on how couples managed their interracial and intercultural differences. To understand their experiences, a qualitative grounded theory analysis was used (n=17). Analysis revealed that couples experienced most issues as cultural...

Anonymous, 1990: From the Centers for Disease Control. Moth-associated dermatitis--Cozumel, Mexico. JAMA 263(18): 2425, 2429-2425, 2429

Orellana, R.J., 2000: Characterization of superficial black root syndrome on rice on the western plains of Venezuela. Pot experiments were conducted at the Adela farm, Araure, Portuguesa state, Venezuela, during June 1997 to January 1998 to characterize superficial black root syndrome (SSRB) on rice plants. The methodology simulated the swampy conditions of the f...

Elahi, M.M.; Everson, N.W., 2004: Prognosis of colorectal cancer patients with elevated endothelin-1 concentrations. Prognostic indicators from clinical, laboratory and pathological data of patients with colorectal cancer are essential to identify high-risk groups in whom adjuvant therapy could be beneficial. Endothelin-1 (ET-1), a growth factor, has been associ...

Aparicio, M.; Chauveau, P.; D.P.écigout, V.; Bouchet, J.L.; Lasseur, C.; Combe, C., 2000: Nutrition and outcome on renal replacement therapy of patients with chronic renal failure treated by a supplemented very low protein diet. Protein-restricted diets are prescribed in patients with chronic renal failure (CRF) to alleviate uremic symptoms and to slow the progression of CRF. The potential deleterious effects of protein restriction on nutritional status and clinical outco...

Kim, J.Kyeoung.; Kim, S.; Han, J.Hee.; Kim, H.Jin.; Chong, S.Young.; Hong, S.Pyo.; Hwang, S.Gyu.; Ahn, J.Yong.; Cha, K.Yul.; Oh, D.; Kim, N.Keun., 2005: Polymorphisms of 5,10-methylenetetrahydrofolate reductase and risk of stomach cancer in a Korean population. Background: Methylentetrahydrofolate reductase plays a central role in converting folate to methyl donor for DNA methylation. Genetic variations in folate metabolism are believed to contribute to the risk of acute lymphoblastic leukemia, colon, es...