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Isolated leptomeningeal Castleman's disease with viral particles in the follicular dendritic cells


, : Isolated leptomeningeal Castleman's disease with viral particles in the follicular dendritic cells. Archives of Pathology & Laboratory Medicine 122(11): 1026-1029

To our knowledge, five cases of Castleman's disease involving only the central nervous system have been reported previously. We report a sixth case, which occurred in a 47-year-old woman with a 3-month history of headaches and a large superior frontal lobe mass on neuroimaging. Excisional biopsy revealed confluent lymphoid nodular areas with multiple well-developed germinal centers surrounded by concentrically layered proliferations of small B lymphocytes typical of Castleman's disease. Ultrastructural study found 100-nm virallike particles within follicular dendritic cells as well as intercellular spaces. These particles were suggestive of a D-type retrovirus. The patient underwent postoperative radiotherapy and was neurologically normal 3 months after surgery.

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PMID: 9822134


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