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Jaspines A and B: Two new cytotoxic sphingosine derivatives from the marine sponge Jaspis sp


, : Jaspines A and B: Two new cytotoxic sphingosine derivatives from the marine sponge Jaspis sp. Tetrahedron Letters 44(2): 225-228

The ethanolic extract of the sponge Jaspis sp. collected in Vanuatu showed cytotoxicity against KB tumour cells (IC95=10 [mu]g/ml). A bioassay-guided fractionation led to the isolation of two new cytotoxic sphingosine derivatives, jaspine A and jaspine B. Structures were elucidated by spectroscopic methods, and absolute configuration by chemical derivatisation. The cytotoxicity of jaspine B hydrochloride was evaluated against the A549 lung tumour cell line (IC50=3.4x10-7 M).

US$19.90

DOI: 10.1002/chin.200314195


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