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Le leflunomide dans le traitement de la polyarthrite rhumatoide


, : Le leflunomide dans le traitement de la polyarthrite rhumatoide. Annales de Medecine Interne 153(1): 21-24

Leflunomide is a new second-line drug for rheumatoid arthritis. This compound with long half-life inhibits proliferation of activated T lymphocytes. Phase III studies have demonstrated a clinical efficacy superior to placebo and identical to comparators (salazopyrine, methotrexate) with a faster onset of response. Improvement of inflammatory paramaters and functional capacity (HAQ) were observed as well as slowing of structural damage evaluated by X-rays.

US$29.90


Other references

Hindwood, K.A., 1964: Birds of the Coral Sea isles. Australian Natural History, 14: 305-311

Ahmed, S.H.; Stinus, L.; Cador, M., 1995: Psychostimulant-induced conditioned activity does not appear to obey to the rules governing the formation of a Pavlovian conditioned behavior. Society for Neuroscience Abstracts 21(1-3): 1466

Boisson, A.; de Anna, P.; Bour, O.; L.B.rgne, T.; Labasque, T.; Aquilina, L., 2013: Reaction chain modeling of denitrification reactions during a push-pull test. Field quantitative estimation of reaction kinetics is required to enhance our understanding of biogeochemical reactions in aquifers. We extended the analytical solution developed by Haggerty et al. (1998) to model an entire 1st order reaction chai...

Freeman, L.A.; Herrod, H.G., 1984: Lack of correlation between two markers of lymphocyte differentiation: 5' nucleotidase activity and T lymphocyte colony formation. Ecto 5' nucleotidase (5' NT) activity and T lymphocyte colony formation (TLCF) are both reputed to be markers for lymphocyte maturation. In order to determine whether these two expressions of lymphocyte activity are related, we compared...

Zauralov, Oa, 1979: Nectar secretion and temperature. Pchelovodstvo ) 14-15

Huang, X-Fei.; Liu, Z-Min.; Geng, Z-Cong.; Zhang, S-Yun.; Wang, Y.; Wang, X-Wang., 2013: Enantioselective construction of multifunctionalized spirocyclohexaneoxindoles through organocatalytic Michael-Aldol cyclization of isatin derived alkenes with linear dialdehydes. Optically active spirocyclohexaneoxindole motifs are very important building blocks for preparations of biologically active complexes, natural products, and pharmaceutical compounds. Herein, we report the syntheses of enantiopure spirocyclohexaneo...

Srivastava A.K.; Ghosh A.K.; Kacker N.K., 1982: Uptake of phosphorus 32 as a function of time and concentration in excised roots of sugarcane. Journal of Nuclear Agriculture & Biology 11(2): 57-58

Stoll U., 1988: Yearly production in 10,000 purification plants of 50 million qm of mud; purified mud used in agriculture. Umwelt (Duesseldorf) 1988(4): 129-130

Grunwald, S.; Thompson, J.A.; Boettinger, J.L., 2011: Digital soil mapping and modeling at continental scales; finding solutions for global issues. Profound shifts have occurred during the last three centuries in which human actions have become the main driver to global environmental change. In this new epoch, the Anthropocene, human-driven changes such as population growth, climate, and land...

Sallon, S.; Ben Arye, E.; Davidson, R.; Shapiro, H.; Ginsberg, G.; Ligumsky, M., 2002: A novel treatment for constipation-predominant irritable bowel syndrome using PadmaReg. Lax, a Tibetan herbal formula. Background and Aims: Padma Lax, a complex Tibetan herbal formula for constipation was evaluated for safety and effectiveness in treating constipation-predominant irritable bowel syndrome in a 3-month double-blind randomized pilot study. Methods: P...