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Le leflunomide dans le traitement de la polyarthrite rhumatoide

, : Le leflunomide dans le traitement de la polyarthrite rhumatoide. Annales de Medecine Interne 153(1): 21-24

Leflunomide is a new second-line drug for rheumatoid arthritis. This compound with long half-life inhibits proliferation of activated T lymphocytes. Phase III studies have demonstrated a clinical efficacy superior to placebo and identical to comparators (salazopyrine, methotrexate) with a faster onset of response. Improvement of inflammatory paramaters and functional capacity (HAQ) were observed as well as slowing of structural damage evaluated by X-rays.


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Boisson, A.; de Anna, P.; Bour, O.; L.B.rgne, T.; Labasque, T.; Aquilina, L., 2013: Reaction chain modeling of denitrification reactions during a push-pull test. Field quantitative estimation of reaction kinetics is required to enhance our understanding of biogeochemical reactions in aquifers. We extended the analytical solution developed by Haggerty et al. (1998) to model an entire 1st order reaction chai...

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Huang, X-Fei.; Liu, Z-Min.; Geng, Z-Cong.; Zhang, S-Yun.; Wang, Y.; Wang, X-Wang., 2013: Enantioselective construction of multifunctionalized spirocyclohexaneoxindoles through organocatalytic Michael-Aldol cyclization of isatin derived alkenes with linear dialdehydes. Optically active spirocyclohexaneoxindole motifs are very important building blocks for preparations of biologically active complexes, natural products, and pharmaceutical compounds. Herein, we report the syntheses of enantiopure spirocyclohexaneo...

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Grunwald, S.; Thompson, J.A.; Boettinger, J.L., 2011: Digital soil mapping and modeling at continental scales; finding solutions for global issues. Profound shifts have occurred during the last three centuries in which human actions have become the main driver to global environmental change. In this new epoch, the Anthropocene, human-driven changes such as population growth, climate, and land...

Sallon, S.; Ben Arye, E.; Davidson, R.; Shapiro, H.; Ginsberg, G.; Ligumsky, M., 2002: A novel treatment for constipation-predominant irritable bowel syndrome using PadmaReg. Lax, a Tibetan herbal formula. Background and Aims: Padma Lax, a complex Tibetan herbal formula for constipation was evaluated for safety and effectiveness in treating constipation-predominant irritable bowel syndrome in a 3-month double-blind randomized pilot study. Methods: P...