+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) serves as an endothelial receptor for advanced glycation end products (AGE)

, : Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) serves as an endothelial receptor for advanced glycation end products (AGE). FEBS Letters 511(1-3): 170-174

Advanced glycation end products (AGE) are known to serve as ligands for the scavenger receptors such as SR-A, CD36 and SR-BI. In the current study, we examined whether AGE is recognized by lectin-like oxidized low density lipoprotein receptor-1 (LOX-1). Cellular binding experiments revealed that AGE-bovine serum albumin (AGE-BSA) showed the specific binding to CHO cells overexpressing bovine LOX-1 (BLOX-1), which was effectively suppressed by an anti-BLOX-1 antibody. Cultured bovine aortic endothelial cells also showed the specific binding for AGE-BSA, which was suppressed by 67% by the anti-BLOX-1 antibody. Thus, LOX-1 is identified as a novel endothelial receptor for AGE.


PMID: 11821070

DOI: 10.1016/s0014-5793(01)03325-7

Other references

Schröder, C.; Engenhart-Cabillic, R.; Vorwerk, H.; Schmidt, M.; Huhnt, W.; Blank, E.; Sidow, D.; Buchali, Aé., 2016: Patient's quality of life after high-dose radiation therapy for thoracic carcinomas : Changes over time and influence on clinical outcome. Quality of life (QoL) is an important factor in patient care. This analysis is focused on QoL before and after radio(chemo)therapy in patients with thoracic carcinomas, as well as on its influence on clinical follow-up and survival, and the correl...

Watkins David C., 2000: Role of geographical information systems and groundwater modelling in water resource management for small islands; a case study from St. Martin's and St. Agnes, Isles of Scilly, UK. Common to other small islands, water resource management is a critical issue on the Isles of Scilly, UK. This study examined the current practice of water management on the islands of St Martin's and St Agnes in the Isles of Scilly so that a...

Matsuura, H., 1949: Chromosome studies on Trillium kamtschaticum Pall and its allies XVIII The role of the kinetochore in trivalent formation. This investigation deals with the mode of trivalent formation and the analysis of trivalent configurations in PMC's. of T. hagae (n = 15), and allotriploid species. The simultaneous pairing of parts of all 3 homologous chromosomes is possible...

Fassari, G., 1999: Census of polychaetes in the Italian seas Opheliidae Malmgren, 1867 Censimento de policheti dei mari italiani Opheliidae Malmgren, 1867. Atti della Societa Toscana di Scienze Naturali Residente in Pisa Memorie Serie B. 1998( ); 105: 45-49

Chao,; Shih,, 2002: Molecular characterization of Lyme disease spirochetes isolated in Taiwan by restriction fragment length polymorphism analysis of 5S -23S intergenic spacer amplicons. We analyzed the 5S (rrf)-23S (rrl) intergenic spacer amplicon gene of Lyme disease spirochetes (Borrelia burgdorferi sensu lato) for the first time in Taiwan. The genetic identities of these Taiwan isolates (TWKM1-7) were clarified by comparing th...

Morel Seytoux Hubert J., 2001: Value and modelling of conjunctive use of surface and ground waters in basin management. In Planning exercises, the interaction between stream and aquifer must be properly described and incorporated in the day-to-day management of the resource within a complex system of economic interests, laws and administrative rules. The manner in...

Packham N.K., 1992: Mitochondria and chloroplasts. Smith, C A And E J Wood Molecular And Cell Biochemistry: Cell Biology Xv+366p Chapman And Hall: London, England, Uk; New York, New York, Usa Illus Paper 118-138

Westwell, Andrew, D., 2004: The therapeutic potential of aryl hydrocarbon receptor (AhR) agonists in anticancer drug development. Agonists of the aryl hydrocarbon receptor (AhR), which in turn induce their own metabolism by cytochrome P-450 isozymes (e.g., CYP1A1) to produce cytotoxic species selectively within cancer cells, represent attractive anticancer drug development c...

Qiu, S-Ben.; Lv, M-Na.; He, X.; Weng, Y-Biao.; Zou, S-Shu.; Wang, X-Qiu.; Lin, R-Qing., 2017: PCR Identification and Phylogenetic Analysis of iTrichomonas gallinae from Domestic Pigeons in Guangzhou, China. Avian trichomoniasis caused by <i>Trichomonas gallinae</i> is a serious protozoan disease worldwide. The domestic pigeon (<i>Columba livia domestica</i>) is the main host for <i>T. gallinae</i> and plays an impo...

Halter J.B., 1986: Norepinephrine release and metabolism in the elderly by compartmental analysis relationship to dietary salt intake. Clinical Research: 950a