+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Long-term brain metabolic alterations in exogenous Cushing's syndrome as monitored by proton magnetic resonance spectroscopy

, : Long-term brain metabolic alterations in exogenous Cushing's syndrome as monitored by proton magnetic resonance spectroscopy. Brain Research 911(2): 134-140, 24 August

The effects of exogenous Cushing's syndrome on the brain metabolism were investigated by proton magnetic resonance spectroscopy (MRS). Thirteen patients having been treated for 2 to 22 years with prednisone were recruited. On the average, none of the metabolites (NAA, Cr, Cho and mI) were significantly different from those of 40 normal subjects in any of the three regions studied: frontal area, thalamus and temporal area. However, the Cho/H(2)O ratios were found to decrease significantly in the thalamic area as a function of treatment period (-1.3%/year). In the frontal and temporal areas, decreases of the Cho/H(2)O ratios were measured with treatment period but they did not reach statistical significance. Effects on Cho levels can be related to those observed for patients with endogenous Cushing's syndrome and suggest an impairment at the membrane level. The Cho/H(2)O reductions were not found to be dose- or age-dependent. Other metabolite ratios did not vary with treatment period, dose or age.


PMID: 11511380

DOI: 10.1016/s0006-8993(01)02697-x

Other references

Siev, J.; Cohen, A.B., 2006: Is thought-action fusion related to religiosity? Differences between Christians and Jews. The purpose of this study was to evaluate the relationship between thought-action fusion (TAF) and religiosity in Christians and Jews (Orthodox, Conservative, and Reform). There is a growing body of evidence that suggests that religiosity is rela...

Aminuddin Mohamad; Salleh Mohd Nor, 1994: Opportunities for commercial rattan planting in Malaysia. Out of 107 rattan species in Peninsular Malaysia, about 20 species are being used by the rattan industry. Due to large consumption by about 640 mills, several species need to be planted on a large scale. The habitat requirements, growth characteri...

Acharya, P.; Chattopadhyaya, J., 2002: The hydrogen bonding and hydration of 2'-OH in adenosine and adenosine 3'-ethyl phosphate. The 2'-OH group has major structural implications in the recognition, processing, and catalytic properties of RNA. We report here intra- and intermolecular H-bonding of 2'-OH in adenosine 3'-ethyl phosphate (1), 3'-deoxyadenosi...

Oesterreich, S.; Weber, L.; Hickey, R.; Fuqua, S.A.W., 1994: Promoter elements involved in either basal or estrogen-induced transcription of the small heat shock protein HSP27 in human breast cancer cells. Journal of Cellular Biochemistry Supplement 0(18B): 370

Pobozy, E.; Halko, R.; Krasowski, M.; Wierzbicki, T.; Trojanowicz, M., 2003: Flow-injection sample preconcentration for ion-pair chromatography of trace metals in waters. Selected trace transition metal ions have been determined in an FIA/HPLC hyphenated system using on-line preconcentration on cellulose functionalised sorbent Cellex P. For HPLC separation ion-pair chromatography was employed with spectrophotometri...

Inaba, Jiro, 1996: Biodosimetry VI Biodosimetry in radiation accidents Case reports. Radioisotopes 45(3): 197-205

Raldúa, D.; Babin, P.J., 2007: BLT-1, a specific inhibitor of the HDL receptor SR-BI, induces a copper-dependent phenotype during zebrafish development. Block lipid transport-1 (BLT-1) is a small chemical widely used to inhibit the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by scavenger receptor B, type 1 (SR-BI). This study demonstrated that BLT-1 induced in zeb...

Morel, P.; Wilson, J.; Clawson, K.; Medsger, T., J., 1996: HLA associations in six groups of SSc patients with distinct anti-nuclear antibodies. Human Immunology 47(1-2): 36

Bray, R.A.; Cribb, T.H., 2000: The status of the genera Hysterolecithoides Yamaguti, 1934, Neotheletrum Gibson & Bray, 1979 and Machidatrema Leon-Regagnon, 1998 (Digenea: Hemiuroidea), including a description of M. leonae n. sp. from Australian waters. A diagnosis is given for the lecithasterid genus Hysterolecithoides, which is now found to have 2 to 6 (possibly 7) vitelline masses. H. frontilatus is returned to the genus, having been considered a member of the bunocotylid genus Neotheletrum by...

Jing, J.Tai; Liu, C.Jin; Zhou, Z.Fan; Hudelist, F.; Yuan, C.Hua; Chen, L.Qing; Li, X.Yun; Qian, J.; Zhang, K.Ye; Zhou, L.; Ma, H.Mei; Dong, G.Jiong; Ou, Z.Yu; Zhang, W.Ping, 2012: Squeezing bandwidth controllable twin beam light and phase sensitive nonlinear interferometer based on atomic ensembles. We review our recent experimental progress in quantum technology employing amplification effect of four-wave mixing in a rubidium vapor. We have produced an intensity difference squeezed light source at frequencies as low as 1.5 kHz which is so fa...