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Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone


, : Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone. Genomics 74(3): 342-351

The MEPE (matrix extracellular phosphoglycoprotein) gene is a strong candidate for the tumor-derived phosphaturic factor in oncogenic hypophosphatemic osteomalacia (OHO). X-linked hypophosphatemia (XLH) is phenotypically similar to OHO and results from mutations in PHEX, a putative metallopeptidase believed to process a factor(s) regulating bone mineralization and renal phosphate reabsorption. Here we report the isolation of the murine homologue of MEPE, from a bone cDNA library, that encodes a protein of 433 amino acids, 92 amino acids shorter than human MEPE. Mepe, like Phex, is expressed by fully differentiated osteoblasts and down-regulated by 1,25-(OH)2D3. In contrast to Phex, Mepe expression is markedly increased during osteoblast-mediated matrix mineralization. Greater than normal Mepe mRNA levels were observed in bone and osteoblasts derived from Hyp mice, the murine homologue of human XLH. Our data provide the first evidence that MEPE/Mepe is expressed by osteoblasts in association with mineralization.

US$19.90

PMID: 11414762

DOI: 10.1006/geno.2001.6553


Other references

Rudolf, M.; Czajka, C.; Börstler, J.; Melaun, C.; Jöst, H.; von Thien, H.; Badusche, M.; Becker, N.; Schmidt-Chanasit, J.; Krüger, A.; Tannich, E.; Becker, S., 2014: First nationwide surveillance of Culex pipiens complex and Culex torrentium mosquitoes demonstrated the presence of Culex pipiens biotype pipiens/molestus hybrids in Germany. Mosquitoes and other arthropods may transmit medically important pathogens, in particular viruses such as West Nile virus. The presence of suitable hosts and competent vectors for those zoonotic viruses is essential for an enzootic transmission, w...

Rossman G.R., 1996: Studies of OH in nominally anhydrous minerals. Hydrous components in nominally anhydrous minerals have been the object of increasing study for the past three decades. OH ions and, less commonly, H2O molecules are found in many anhydrous minerals at concentrations ranging from ppms to tenth&apo...

Nowack, B.; Schulin, R.; Luster, Jörg., 2011: Metal fractionation in a contaminated soil after reforestation: temporal changes versus spatial variability. In a lysimeter experiment, topsoils were polluted with filter dust from a non-ferrous metal smelter and then planted with trees. Sequential extractions were used to follow the changes in metal fractionation of Cu, Zn, Cd, and Pb over 42 months. Pl...

Rosenørn, J.; Diemer, N., 1985: The risk of cerebral damage during graded brain retractor pressure in the rat. A considerable reduction in regional cerebral blood flow has been demonstrated with brain retraction at a pressure of 30 mm Hg. The authors undertook a neuropathological study to assess the effect on brain tissue of brain retractors applied at var...

Xiang, J.Yan.; Zhao, Y.Wu.; Fu, J.Liang.; Cheng, X.Juan.; Xue, Q.; Wang, Y., 2013: Clinicopathological features of Churg-Strauss syndrome with severe nerve degeneration: a case report. Churg-Strauss syndrome (CSS) is a rare autoimmune vasculitis of unknown etiology that involves small- and medium-sized blood vessels. Its onset is thought to be associated with adult-onset asthma, and vasculitis typically involves vessels in the l...

Val'dman, A.V.; Medvedev, O.S., 1978: Modulation of autonomic correlates of emotional stress and adaptive responses. The character and dynamics of the cardio-vascular response to psychogenic stress (confrontation of cat and dog) depends on active or passive type of behavioral response. Tranquilizers inhibit long-lasting hypertension otherwise occurring after the...

Hamilton P.J.; Fallick A.E.; Macintyre R.M.; Elliott S., 1987: Isotopic tracing of the provenance and diagenesis of lower Brent Group sands, North Sea. Pages 939-949 1987

Vráblik, V.; Trupl, J.; Pavlovic, M.; Horváth, A.; Nespor, V., 1989: Is Campylobacter pylori the pathogenic agent in gastritis and peptic ulcer?. The authors analyzed a group of 164 subjects where they collected during gastroduodenoscopy specimens of the gastric mucosa for histological and microbiological examination. Campylobacter pylori (CP) was detected in 37 of 41 subjects with gastriti...

Quilliam, S., 2007: What did you do at school today dear?. Journal of Family Planning and Reproductive Health Care 33(4): 280-282

Wright S.W.; Jeffrey S.W.; Mantoura R.F.C.; Llewellyn C.A.; Bjornland T.; Repeta D.; Welschmeyer N., 1991: Improved hplc method for the analysis of chlorophylls and carotenoids from marine phytoplankton. Using a ternary gradient system, ove 50 carotenoids, chlorophylls and their derivatives were separated from marine phytoplankton. Only 2 pairs of carotenoid pigments (19'-butanoyloxyfucoxanthin and siphonaxanthin, and 19'-hexanoyloxyfuco...