+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Mechanisms of ventricular fibrillation induction by 60-Hz alternating current in isolated swine right ventricle

, : Mechanisms of ventricular fibrillation induction by 60-Hz alternating current in isolated swine right ventricle. Circulation 102(13): 1569-1574

Background-The mechanisms by which 60-Hz alternating current (AC) can induce ventricular fibrillation (VF) are unknown. Methods and Results-We studied 7 isolated perfused swine right ventricles in vitro. The action potential duration restitution curve was determined. Optical mapping techniques were used to determine the patterns of activation on the epicardium during 5-second 60-Hz AC stimulation (10 to 999 muA). AC captured the right ventricles at 100 +- 65 muA, which is significantly lower than the direct current pacing threshold (0.77 +- 0.45 mA, P < 0.05). AC induced ventricular tachycardia or VF at 477 +- 266 muA, when the stimulated responses to AC had (1) short activation CLs (128 +- 14 ms), (2) short diastolic intervals (16 +- 9 ms), and (3) short diastolic intervals associated with a steep action potential duration restitution curve. Optical mapping studies showed that during rapid ventricular stimulation by AC, a wave front might encounter the refractory tail of an earlier wave front, resulting in the formation of a wave break and VF. Computer simulations reproduced these results. Conclusions-AC at strengths less than the regular pacing threshold can capture the ventricle at fast rates. Accidental AC leak to the ventricles could precipitate VF and sudden death if AC results in a fast ventricular rate coupled with a steep restitution curve and a nonuniform recovery of excitability of the myocardium.


PMID: 11004149

DOI: 10.1161/01.CIR.102.13.1569

Other references

Baghel, R.K.S.; Kotasthane, S.R.; Khare, M.N.; Gupta, O., 1985: Efficacy of seven methods in the detection of three Fusarium species associated with moong seeds. The highest counts of F. moniliforme [Gibberella fujikuroi] from seeds [of Vigna radiata] were detected by the agar plate method, F. semitectum [F. pallidoroseum] by the standard blotter method. None of the techniques was efficient for F. solani.

Robson, A.M.; Roberts, H.; Hollowood, K.; Geradts, J., 2001: Common abrogation of the G1 cell cycle checkpoint in malignant melanoma. Laboratory Investigation 81(1): 72A, January

Cloos Mark, 1993: Lithospheric buoyancy and collisional orogenesis; subduction of continental margins, island arcs, and oceanic plateaus. Abstracts with Programs - Geological Society of America 25(6): 70-71

Keane, J.F.; Ellison, R.C.; Rudd, M.; Nadas, A.S., 1973: Pulmonary blood flow and left ventricular volumes in transposition of the great arteries and intact ventricular septum. British Heart Journal 35(5): 521-526

Anonymous, 2013: Aroma-active Components of Yeast Extract Pastes with Basic and Characteristic Meaty Flavor. Aroma-active compounds, together with sugars, amino acids, fat and nucleotide, are the main chemical species determining the characteristic aroma and taste of food. For selecting yeast extract pastes products with a less undesirable aroma, the aro...

Gysel, L.W.; Davis, E.M., 1956: A simple automatic photographic unit for wildlife research. The unit consists of an inexpensive camera with a synchronized flash attachment and a simple electrically operated device for releasing the shutter. This shutter-releasing mechanism consists of a solenoid, a spring-driven wire, 2 knife switches, a...

Bie, W.; Squire, J.A.; Fraser, M.; Paterson, M.C.; Godbout, R., 1995: Mitochondrial ATP synthase alpha-subunit gene amplified in a retinoblastoma cell line maps to chromosome 18. The human retinoblastoma cell line Y79 has multiple copies of the MYCN gene and the DEAD box gene DDXI. Both genes have been mapped to chromosome band 2p24. A third gene, encoding the alpha-subunit of mitochondrial ATP synthase (ATPSA), is also am...

Williams, J.Schlabig., 2011: Strategic planning process sets stage for success. Biomedical Instrumentation & Technology 45(5): 388-391

Casco, J.F.; Bernardis, A.C.; Goldfarb, M.C., 1996: Chemical composition variation under three simulated management strategies of Andropogon lateralis Nees. Chemical composition of Andropogon lateralis was determined under 3 simulated forage management situations and related to plant age (cutting at 28- or 56-day intervals, or regrowth permitted for up to 392 days). Seasonal fluctuations in forage qua...

Balandin, S.A.; Gubanov, I.A.; Javis, C.E.; Schmid, R., R., 2001: Herbarium Linnaeanum (book review). Taxon 50(4): 87