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Modulation by substrates of the protective effect of cyclosporin A on mitochondrial damage

, : Modulation by substrates of the protective effect of cyclosporin A on mitochondrial damage. Life Sciences 70(20): 2413-2420, April 5

The influence of substrates on the role of cyclosporin A, to promote the closure of the permeability transition pore, was studied. It was found that in succinate-oxidizing mitochondria, cyclosporin inhibited pore opening as induced by carboxyatractyloside. The opposite occurred when mitochondrial respiration was supported by malate-glutamate, i.e., cyclosporin A was unable to block pore opening promoted by carboxyatractyloside. We propose that the failure of cyclosporin A to induce pore closure could be due to a low NADH matrix content.


PMID: 12150205

DOI: 10.1016/s0024-3205(02)01486-8

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