+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Mouse Sprr2 genes: a clustered family of genes showing differential expression in epithelial tissues

, : Mouse Sprr2 genes: a clustered family of genes showing differential expression in epithelial tissues. Genomics 55(1): 28-42

Small proline-rich (SPR) proteins are structural components of the cornified cell envelope of stratified squamous epithelia. They are subdivided into three families, i.e., SPR1, SPR2, and SPR3, of which the SPR2 family is the most complex. To understand the significance of this complexity, we have isolated 11 mouse Sprr2 genes, constructed a provisional physical map of the Sprr2 locus on mouse Chromosome 39 and examined the expression patterns of the Sprr2 genes in mouse epithelial tissues. The 11 Sprr2 sequences are highly conserved with a central domain containing a variable number of repeats. In situ hybridization showed the sprr2 expression to be confined to epithelia. RT-PCR using primers specific for each of the 11 Sprr2 members demonstrated varying degrees of expression among the individual SPrr2 members in different tissues. The correlation between the physical location of the genes in the Sprr2 locus and their expression patterns suggests multiple levels of controlled expression.


PMID: 9888996

DOI: 10.1006/geno.1998.5607

Other references

Kim, E.Hee.; Kim, D.Hee.; Kim, H.Ree.; Kim, S.Yoon.; Kim, H.Ho.; Bang, O.Young., 2016: Stroke Serum Priming Modulates Characteristics of Mesenchymal Stromal Cells by Controlling the Expression miRNA-20a. Transplantation of mesenchymal stem cells (MSCs) expanded with fetal bovine serum (FBS) has some limitations, including the requirement of a long culture period to obtain a sufficient amount of stem cells. Priming of MSCs with serum from patients...

Schaaf, S.W., 1991: Changes come to radiation regs; how will your facility be affected?. Occupational Health & Safety 60(7): 58-60

Polak J.M.; Bloom S.R., 1984: Localization and measurement of vasoactive intestinal polypeptide in the genitourinary system of man and animals. Peptides (New York) 5(2): 225-230

Regan, J.; Smalley, M., 2007: Prospective isolation and functional analysis of stem and differentiated cells from the mouse mammary gland. Prospective isolation and in vitro and in vivo analysis of primary mouse mammary epithelial cells has been used to separate cell subpopulations and identify stem, progenitor and differentiated cell compartments. Progress has been made from cell se...

Whitfield, K.Lynette.; Shulman, R.J., 2009: Treatment options for functional gastrointestinal disorders: from empiric to complementary approaches. Pediatric Annals 38(5): 288-90, 292-4

Bieri, John G., 1961: The nature of the action of selenium in replacing vitamin E. AMER JOUR CLIN NUTRITION 9(4 Pt 2): 89-96

Lakhtin, V.M.; Lakhtin, M.V.; Afanas'ev, S.S.; Aleshkin, V.A.; Nesvizhskiĭ, I.V.; Pospelova, V.V., 2008: General properties and functioning principles of lectins in biological systems. The authors give the literature review with analysis of main conceptions of lectins - their structure and functions according to state-of-the-art science and production requirements. Up-to-date definition of lectins based on last achievements of...

Hasumura, Y.; Ikegami, F.; Takada, A.; Takeuchi, J., 1972: Significance of serum gamma-glutamyl transpeptidase activities in the diagnosis of chronic hepatic diseases. Nihon Rinsho. Japanese Journal of Clinical Medicine 30(4): 1023-1029

Greenberg, N.L.; Vandervoort, P.M.; Firstenberg, M.S.; Garcia, M.J.; Thomas, J.D.; Thomas, J.D., 2001: Estimation of diastolic intraventricular pressure gradients by Doppler M-mode echocardiography. Previous studies have shown that small intraventricular pressure gradients (IVPG) are important for efficient filling of the left ventricle (LV) and as a sensitive marker for ischemia. Unfortunately, there has previously been no way of measuring t...

Rhodes G.; Chamberlin M., 1974: The kinetics of rna synthesis by dna dependent rna polymerase. Federation Proceedings 33(5 PART 2): 1602