+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Multiple potential intragenic regulatory elements in the CFTR gene

, : Multiple potential intragenic regulatory elements in the CFTR gene. Genomics 64(1): 90-96

The CFTR gene exhibits a complex pattern of expression that shows temporal and spatial regulation though the control mechanisms have not been fully elucidated. We have mapped DNase I hypersensitive sites (DHS) flanking the CFTR gene to identify potential regulatory elements. We previously characterized DHS at -79.5 and -20.9 kb with respect to the CFTR translational start site, DHS 3' to the gene at 4574 + 5.4-7.4 and 4574 + 15.6 kb, and a regulatory element in the first intron of the gene at 185 + 10 kb. We generated a cosmid contig to provide probes to evaluate the whole of the CFTR gene for DHS and have now mapped novel sites in introns 2, 3, 10, 16, 17a, 18, 20, and 21. These DHS show different patterns of cell-specific expression.


PMID: 10708521

DOI: 10.1006/geno.1999.6086

Other references

Luttropp, H.-Henrik; Thomasson, R.; Dahm, S.; Persson, J.; Werner, O., 1994: Clinical experience with minimal flow xenon anesthesia. Xenon is a more potent anesthetic than nitrous oxide, and gives more profound analgesia. This investigation was performed to assess the potential of xenon for becoming an anesthetic inspite of its high manufacturing cost. Seven ASA I-II patients u...

Hager, H., 1963: Examination of cerebral circulation by means of ophthalmodynamography. Die Medizinische Welt 18: 995-1004

Thomas D.C., 1987: Symposium on time related factors in cancer epidemiology bethesda maryland usa april 15 17 1985. Journal of Chronic Diseases 40(SUPPL 2): 1S-211S

Christison, G.I., 1996: Dim light does not reduce fighting or wounding of newly mixed pigs at weaning. Pigs weaned at 27 d were mixed into groups of nine and exposed to constant illumination of 5 or 100 lx. Behavior was categorized every 10 min for 72 h and all fights were counted. Eating, drinking, lying and fighting patterns were similar in both...

Roesel, C., 1988: From relief to development: supplementary feeding among Khmer refugees. The CARE supplementary feeding programmes in refugee and displaced person camps in Thailand were radically restructured in 1984 and 1985. The goal was to emphasize nutrition education and mothers' feeding skills. This article outlines the rev...

Copley, L.; Tierney, T.; Kane, F.; Naughton, O.; Kennedy, S.; O'donohoe, P.; Jackson, D.; Mcgrath, D., 2005: Sea lice, Lepeophtheirus salmonis and Caligus elongatus, levels on salmon returning to the west coast of Ireland, 2003. Mobile lice levels of two species of sea lice, Lepeophtheirus salmonis and Caligus elongatus, were examined on two samples of Atlantic salmon from the west coast of Ireland. The samples examined were taken two weeks apart from salmon caught by dri...

NOVIKOV.A.Kh.; TRAKHTENBERG.A.Kh.; CH'UAN.W., 1959: On the prevention of complications arising during angiopneumography. Voprosy Onkologii 5: 592-599

Danilova, T.V.; Danilov, S.S.; Karlov, G.I., 2004: Molecular-genetic polymorphisms of cultivars of common hops (Humulus lupulus L.) using ISSR-PCR analysis. Genetic diversity among 26 Russian and European cultivars of the common hop (Humulus lupulus L.) was studied using the ISSR-PCR technique. Twenty-one primers used provided amplification of 183 DNA fragments, 106 of which (57.9%) were found to be p...

Aral, F.; Dogu, Z.; Selcuk, B.; Tath, M.; Saitkilic, O., 2004: Determination of the spermatological properties during the first spawning season of young male rainbow trouts (Oncorhynchus mykiss) reared in floating cages in Ataturk Dam Lake, Sanliurfa, Turkey. Semen was collected by abdominal massage from 11 young male rainbow trout during the spawning season (late January to late February). The colour, volume, motility, motility duration, concentration and pH of the collected milts were determined. Fur...

Foscue, E.P.; Wood, K.N.; Schramm-Sapyta, N.L., 2012: Characterization of a semi-rapid method for assessing delay discounting in rodents. Delay discounting is a key component of many psychiatric disorders, including drug addiction, compulsive gambling, ADHD, and obesity. However, its underlying mechanisms are not yet fully characterized. One impediment to full characterization of su...