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Neonatal ethanol produces cerebellar deep nuclear cell loss and correlated disruption of eyeblink conditioning in adult rats


, : Neonatal ethanol produces cerebellar deep nuclear cell loss and correlated disruption of eyeblink conditioning in adult rats. Brain Research 956(2): 302-311, 29 November

Binge-like neonatal exposure to ethanol (EtOH) in rats, during the period of brain development comparable to that of the human third trimester, produces significant, dose-dependent Purkinje cell loss in the cerebellum and deficits in eyeblink classical conditioning. There are currently no published reports of whether neuronal loss in the cerebellar deep nuclei also results from binge-like neonatal exposure to EtOH and what the functional consequences of any cell loss might be. Since eyeblink conditioning requires cerebellar deep nuclear cells for normal learning to occur, we examined the effects of binge-like neonatal EtOH exposure on the total number of deep nuclear cells and eyeblink conditioning in adult rats. Group Ethanol (n=11) received EtOH doses of 5.25 g/kg/day on postnatal days 4-9, producing average peak blood alcohol concentrations of 363 mg/dl. Group Sham Intubated (n=11) underwent acute intragastric intubation on postnatal days 4-9 but did not receive any EtOH infusions. Group Unintubated Control (n=10) did not receive any intubations. When rats were at least 3 months old, they received either paired eyeblink conditioning or unpaired training. Following training, estimates of the total number of cerebellar deep nuclear cells were obtained using the optical fractionator, an unbiased stereological counting procedure. Rats in Group Ethanol had approximately 50% fewer deep nuclear cells compared to rats in Groups Sham Intubated and Unintubated Control, which did not differ. For 21 rats that received paired eyeblink conditioning, a highly significant correlation (+0.80) was found between the number of deep nuclear cells and learning rate in eyeblink conditioning.

US$19.90

PMID: 12445699

DOI: 10.1016/s0006-8993(02)03561-8


Other references

Tamura Y., 1985: Step synthesis of the erythrinane skeleton by acid promoted double cyclization of n cyclohex 1 enyl n 2 3 4 dimethoxyphenylethyl alpha methylsulfinylacetamide and its derivatives. On being heated with toluene-p-sulfonic acid, N-(cyclohex-1-enyl)-N-[2-(3,4-dimethoxyphenyl)-ethyl]-.alpha.-(methylsulphinyl)acetamide underwent double cyclization to give the erythrinane derivative, which was converted into the amide by reduction...

Liu, B.; Macdonald, E.A.; Stamper, D.L.; Brezinski, M.E., 2004: Group velocity dispersion effects with water and lipid in 1.3 microm optical coherence tomography system. Optical coherence tomography (OCT) has been introduced for the diagnosis of vulnerable plaques in the coronary arteries. When an OCT system images through tissue and biological liquids, group velocity dispersion (GVD) will occur, which may be usef...

Berezkin, V.G.; Korolev, A.A.; Malyukova, I.V.; Popova, T.P.; Shiryaeva, V.E.; Khotimskii, V.S., 2002: Poly[1-(trimethylsilyl)-1-propine] as chromatographic adsorbent and prospects of its application in packed and capillary columns. The application of film-forming organic polymers, which are in common use in membrane technology, as chromatographic adsorbents for packed and capillary columns has been suggested. The chromatographic characteristics of poly[1-(trimethylsilyl)-1-p...

Machulka, V., 1938: Neue palae-arktische Neuraphes-Arten. Acta Societatis Entomologicae Cechoslovenicae, 35: 106-111

Lecomte, J., 1952: Current therapy of asthmatic disease. Revue Medicale de Liege 7(15): 500-507

Petrov, E.; Rohde, P.R.; Cornell, B.; Martinac, B., 2013: The protective effect of osmoprotectant TMAO on bacterial mechanosensitive channels of small conductance MscS/MscK under high hydrostatic pressure. Activity of the bacterial mechanosensitive channels of small conductance MscS/MscK of E. coli was investigated under high hydrostatic pressure (HHP) using the "flying-patch" patch-clamp technique. The channels were gated by negative pipe...

Crisosto, G.-Ggsyc, 1982: Delicious apple fruit shape in several Chilean orchards. Ciencia e investigacion agraria 9(2): 95-101

Anonymous, 2011: Comparison of two real-time RT-PCR-based systems for the detection and typing of the pandemic influenza A virus, 29. During the 29 pandemic the Virology laboratory of L. Spallanzani, Rome, Italy, adopted a real-time RT-PCR developed by the Centers for Disease Control and Prevention (CDC), Atlanta, Georgia to diagnose pandemic influenza A/H1N1 (H1N1pdm). A new mu...

Shao, J.; Gu, M.; Zhang, Z.; Xu, Z.; Hu, Q.; Qian, L., 2008: Genetic variants of the cytochrome P450 and glutathione S-transferase associated with risk of bladder cancer in a south-eastern Chinese population. To evaluate the association between genetic polymorphisms of CYP2E1 RsaI and GSTM1 and development of bladder cancer in a south-eastern Han Chinese population. We hypothesized that the CYP2E1-1019T>A and GSTM1 polymorphisms were associated with...

Fissgus Siegfried; Fissgus Christian, 1995: Computer-aided planning of underground working of very strong coal seams. Glueckauf (Essen) 131(9): 419-424