geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Neurotransmitter levels in two populations of larval Fundulus heteroclitus after methylmercury exposure


, : Neurotransmitter levels in two populations of larval Fundulus heteroclitus after methylmercury exposure. Comparative Biochemistry & Physiology C Pharmacology Toxicology & Endocrinology 124(3): 287-294, Nov

The effects of methylmercury (MeHg) exposure on neurotransmitter (NT) levels in larval mummichogs (Fundulus heteroclitus) obtained from a mercury-polluted site (Piles Creek (PC), NJ) and a reference site (Tuckerton (TK), NJ) were examined. Population differences between PC and TK larvae in neurochemical composition and in neurochemical changes in response to MeHg intoxication were found. Heads of untreated PC larvae (7 days posthatch (dph)) contained considerably higher levels of dopamine (DA) and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) than TK. However, they had comparable levels of serotonin (5-hydroxytryptamine (5-HT)) and 5-hyroxy-3-indoleacetic acid (5-HIAA)/5-HT ratios. Changes in NTs with age were noticed, especially in PC larvae. Exposure of larvae to 10 mug/l MeHg induced neurochemical alterations. A significant increase in DA and 5-HT, as well as depressed dopaminergic and serotonergic activity (i.e. decreased DOPAC/DA, HVA/DA and 5-HIAA/5-HT ratios) were seen in TK larvae. Exposure of PC larvae to 10 mug/l MeHg reduced 5-HT at 14 dph, increased serotonergic activity at 7 dph, and altered dopaminergic activity (i.e. increased DOPAC/DA ratios, but decreased HVA/DA ratios). Changes in DA levels were inconsistent over time. The DA level, which was considerably higher than the control at 7 dph, was significantly lower than the control at 14 dph. For the two populations, the level of 5-HT and serotonergic activity, as well as DOPAC and HVA levels, were correlated with previously noted spontaneous activity. The changes in NT levels after exposure to MeHg are an indication of neurological dysfunction in larvae.

US$19.90

DOI: 10.1016/s0742-8413(99)00077-8


Other references

Kheoruenromne I.; Sharp W.E.; Gardner L.R., 1976: Variation of link magnitude with map scale. Water Resources Research 12(5): 919-923

Cohen, D.C.; Mered, M.; Simmons, R.; DadsonAlfred C.Jr.; Figueroa, C.; Rice, C.W., 1992: Systems for large-scale continuous perfusion of mammalian cells grown in suspension. Ladisch, M R [Editor], Bose, A [Editor] ACS Conference Proceedings Series; Harnessing biotechnology for the 21st century : 211-214

Marhefka, C.A.; Moore, B.M.II.D.lton, J.T.; Miller, D.D., 1999: Model for the human androgen receptor ligand binding domain using molecular dynamics simulations. Abstracts of Papers American Chemical Society 218(1-2): MEDI 218

Yang, J.B.ssler, D.; Leatham, D., 2000: The law of one price: developed and developing country market integration. Journal of agricultural and applied economics 32(3): 429-440

Higgins, T.J.; Winston, C.T.; David, J.R., 1976: Effect of migration inhibitory factor (MIF) on cyclic AMP levels of guinea pig macrophages. Cellular Immunology 27(1): 11-16

Fauvert, R.; Loverdo, A., 1962: Hepatic photoscintigraphy by the radioactive colloidal gold technic. Archives des Maladies de L'appareil Digestif et des Maladies de la Nutrition 51: 43-54

Vetter D.; Paris Bockel D.; Doffoel M.; Brogard J M.; Blicke J F.; Dorner M.; Bockel R., 1986: Deficiency of insulin secretion and denutrition during cirrhosis of the liver. Gastroenterologie Clinique et Biologique 10(1): 81-82

Ozesmi, S.L.; Ozesmi, U., 1999: An artificial neural network approach to spatial habitat modelling with interspecific interaction. Spatial models for habitat selection of marsh-breeding bird species were developed using artificial neural networks. The habitat models included single and multiple species artificial neural networks for red-winged blackbird (Agelaius phoeniceus)...

Büla, C.J.; Wietlisbach, V.; Yersin, B.; Burnand, B., 2003: Does a single item question identify elderly medical inpatients who report significant depressive symptoms?. Age and Ageing 32(2): 231-233

Mattiasson, B., 2017: Conquering climate change: The vital role of industrial biotechnology to meet Paris Agreement's ambitious goals. Biotechnology Reports 11: 1-1