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Nitric oxide mediates a therapeutic effect of nicotine in ulcerative colitis


, : Nitric oxide mediates a therapeutic effect of nicotine in ulcerative colitis. Alimentary Pharmacology & Therapeutics 14(11): 1429-1434, November

Background: Ulcerative colitis is a condition of nonsmokers in which nicotine is of therapeutic benefit. Aims: To examine the in vitro effect of nicotine on colonic smooth muscle activity and the role of nitric oxide (NO) as a mediator. Methods: Nicotine, 1-10 muM, was administered to strips of circular muscle from the distal sigmoid colon of 9 patients with active ulcerative colitis and 18 with colorectal cancer. The effect of electrical field stimulation (EFS) was examined before nicotine was added. Finally L-NAME, a NO synthetase inhibitor, was added before nicotine was administered again. Results: Muscle strips developed similar spontaneous resting tone. In response to EFS, ulcerative colitis tissue developed lower tensions than the controls. Nicotine significantly reduced the resting tone and peak tension after EFS, with a greater effect in controls. With L-NAME, peak tensions were increased more in ulcerative colitis than controls, and nicotine produced a much smaller reduction. Conclusions: Nicotine reduces circular muscle activity, predominantly through the release of nitric oxide-this appears to be 'up-regulated' in active ulcerative colitis. These findings may explain some of the therapeutic benefit from nicotine (and smoking) in ulcerative colitis and may account for the colonic motor dysfunction in active disease.

US$19.90

PMID: 11069313

DOI: 10.1046/j.1365-2036.2000.00847.x


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Mukaddam, A.; Patil, R.; Jadli, A.; Chandrakala, S.; Ghosh, K.; Shetty, S., 2015: Paradoxical bleeding and thrombosis in a patient with afibrinogenemia and fibrinogen Mumbai mutation. Thrombosis is rarely reported in cases of afibrinogenemia and is generally associated with thrombophilia or replacement therapy. Often, it is difficult to predict whether the patients will bleed or whether they are exposed to the risk of thrombosi...

Méthot, N.; Ritchie, B.D.; Blanton, M.P.; Baenziger, J.E., 2001: Structure of the pore-forming transmembrane domain of a ligand-gated ion channel. The structure of the pore-forming transmembrane domain of the nicotinic acetylcholine receptor from Torpedo has been investigated by infrared spectroscopy. Treatment of affinity-purified receptor with either Pronase or proteinase K digests the ext...

Choisez-Givron, D., 1985: Sexual reproduction in the genus Fuchsia. Embryogenesis in Fuchsia fulgens. Sexual reproduction in seed plants ferns and mosses: proceedings 8th international symposium 20-24 August 1984 Wageningen the Netherlands MTM Willemse and JL van Went compilers

Marley, R.; Lu, W.; Balment, R.J.; McCrohan, C.R., 2007: Evidence for nitric oxide role in the caudal neurosecretory system of the European flounder, Platichthys flesus. A neuromodulatory role for nitric oxide has been reported for magnocellular neuroendocrine cells in mammalian hypothalamus. We examined its potential as a local intercellular messenger in the neuroendocrine Dahlgren cell population of the caudal n...

Popescu, V., 1975: Aspects of Japanese vegetable growing. Productia vegetala: 24 (9) 41-43

Lechner A.J., 1984: Growth retardation and mortality in guinea pigs following perinatal starvation. To study the magnitude and reversibility of growth retardation induced by caloric restriction, guinea pigs were provided wiht a 50% ration of normal food intake for 21 days at 1 of 3 perinatal ages: during the last trimester of the 67 day gestatio...

Weyer, F.; Zumpt, F., 1942: Insects and Arachnida injurious to health in the tropics. This book is intended for farmers and other Europeans living in the tropics, particularly in Africa, but is said to be of value for its information about the injurious species of insects in other warm climates, and even Europe. In the general sect...

Gruener, S.; Huber, P., 2011: Imbibition in mesoporous silica: rheological concepts and experiments on water and a liquid crystal. We present, along with some fundamental concepts regarding imbibition of liquids in porous hosts, an experimental, gravimetric study on the capillarity-driven invasion dynamics of water and of the rod-like liquid crystal octyloxycyanobiphenyl (8OC...

Ibodullaev, O.N.; Asrarov, M.I.; Kalikulov, D.; Gagel'gans, A.I.; Usmanov, P.B., 2002: Effects of glycyrrhetic acid on transmitter secretion. The investigation of the effects of glycyrrhetic acid on spontaneous secretion of transmitter from neurotermination of the frog neuromuscular synapses showed that this substance, unlike glycyrrhizic acid, increased the frequency and amplitude of m...

Sugai, T.; Habano, W.; Uesugi, N.; Jao, Y.-Fei; Nakamura, S.-Ichi; Abe, K.; Takagane, A.; Terashima, M., 2004: Three independent genetic profiles based on mucin expression in early differentiated-type gastric cancers - a new concept of genetic carcinogenesis of early differentiated-type adenocarcinomas. Recent molecular studies have shown that the genetic profiles of differentiated-type adenocarcinomas of the stomach are associated with distinct cellular mucin phenotypes (gastric-intestinal- and mixed-phenotypes). Therefore, we examined whether t...