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Omeprazole has a dual mechanism of action: it inhibits both H(+)K(+)ATPase and gastric mucosa carbonic anhydrase enzyme in humans (in vitro and in vivo experiments)


, : Omeprazole has a dual mechanism of action: it inhibits both H(+)K(+)ATPase and gastric mucosa carbonic anhydrase enzyme in humans (in vitro and in vivo experiments). Journal of Pharmacology and Experimental Therapeutics 290(2): 530-534

In this study our experiments followed in vitro and in vivo the effect of omeprazole on purified and erythrocyte carbonic anhydrase (CA) I and II isozymes, as well as on gastric mucosa CA IV in humans. Our in vitro results show that omeprazole-induced inhibition of purified CA I and CA II and gastric mucosa CA IV is dose- and pH-dependent.

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PMID: 10411559


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Avery, C.M.E.; Bujtár, Péter.; Simonovics, János.; Dézsi, Tás.; Váradi, Károly.; Sándor, G.K.B.; Pan, J., 2014: A finite element analysis of bone plates available for prophylactic internal fixation of the radial osteocutaneous donor site using the sheep tibia model. The strengthening effect of prophylactic internal fixation (PIF) with a bone plate at the radial osteocutaneous flap donor site has previously been demonstrated using the sheep tibia model of the human radius. This study investigated whether a fin...

Wolter, R.G.andjean, D., 1983: Feeding sleight dogs. 2. An adapted ration. Recueil de medecine veterinaire59(2): 81-87

Favus, M.J.; Coe, F.L., 1997: Idiopathic hypercalciuria and nephrolithiasis. This chapter reviews idiopathic hypercalciuria (IH) as the cause of hypercalciuria and nephrolithiasis. Most IH patients have increased intestinal calcium absorption and serum calcitriol levels are elevated in one-third to one-half of patients. El...

Sivakumaran, K.; Bao, Y.; Roossinck, M.J.; Kao, C.C., 2000: Recognition of the core RNA promoter for minus-strand RNA synthesis by the replicases of Brome mosaic virus and Cucumber mosaic virus. Replication of viral RNA genomes requires the specific interaction between the replicase and the RNA template. Members of the Bromovirus and Cucumovirus genera have a tRNA-like structure at the 3' end of their genomic RNAs that interacts with...

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Bezerra, J.A.; Bugge, T.H.; Melin-Aldana, H.; Sabla, G.; Kombrinck, K.W.; Witte, D.P.; Degen, J.L., 1999: Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver. Cellular proliferation and tissue remodeling are central to the regenerative response after a toxic injury to the liver. To explore the role of plasminogen in hepatic tissue remodeling and regeneration, we used carbon tetrachloride to induce an ac...

M.J.arui; Shao Mihua, 1994: Variation in heavy metal pollution of offshore sedimentary cores in Jinzhou Bay. Zhonggou Huanjing Kexue = China Environmental Science 14(1): 22-29

Hangay, G., 2001: Notes on Australian Cetoniinae research. Cetoniimania. Octobre; 15: 122-127

Margineanu, R.M.; Blebea-Apostu, A-Maria.; Celarel, A.; Gomoiu, C-Mariana.; Costea, C.; Dumitras, D.; Ion, A.; Duliu, O.G., 2015: Radiometric, SEM and XRD investigation of the Chituc black sands, southern Danube Delta, Romania. The black sand of the Chituc marine sand bank, northern of the city of Navodari (Romania), presents anomalous high radioactivity. Field measurements recorded in some places dose rate up to 200 nSv/h, significantly overpassing the average value of...

Anonymous, 2012: Reviewers. Journal of the Pediatric Infectious Diseases Society 1(4): E1-E2