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On-line extraction-spectrophotometric determination of neostigmine in pharmaceuticals using double membrane phase separator and monovalent dyestuff


, : On-line extraction-spectrophotometric determination of neostigmine in pharmaceuticals using double membrane phase separator and monovalent dyestuff. Talanta 49(5): 997-1001, Aug 9

A simple, sensitive and rapid spectrophotometric method for the determination of neostigmine by flow injection analysis (FIA) coupled with an ion associate extraction has been developed. The three-line manifold was assembled. Neostigmine(200 mul) was injected into a distilled water stream and the pH was adjusted to 10 with a borate-phosphate buffer solution. Then, the stream was mixed with the ion-pairing tetrabromophenolphthalein ethylester (TBPEH)-1,2-dichloroethane solution. After phase separation with a double membrane phase separator, absorbance was measured at 610 nm. A linear calibration graph was obtained between 1 X 10-7 mol l-1 and 5 X 10-7 mol l-1 of neostigmine. Up to 48 samples h-1 could be processed with a relative standard deviation (R.S.D.) of 0.5% (n = 5) for 4 X 10-7 mol l-1 neostigmine. The proposed system was applied to the simple, reproducible and rapid determination of neostigmine in commercial pharmaceuticals.

US$19.90

DOI: 10.1016/s0039-9140(99)00017-x


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McGeoghegan, D.; Binks, K.; Gillies, M.; Jones, S.; Whaley, S., 2008: The non-cancer mortality experience of male workers at British Nuclear Fuels plc, 1946-2005. Recent studies of the Hiroshima and Nagasaki A-bomb survivors, together with some (but not all) cohorts exposed occupationally or medically to ionizing radiation, have found an increasing trend in mortality from non-malignant disease with increasi...

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