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Open maintenance treatment of bipolar disorder spectrum patients who responded to gabapentin augmentation in the acute phase of treatment

, : Open maintenance treatment of bipolar disorder spectrum patients who responded to gabapentin augmentation in the acute phase of treatment. Journal of Affective Disorders 55(2-3): 237-240, Oct

This report describes the results of maintenance treatment with gabapentin in 18 previously refractory Bipolar Disorder patients who initially responded to augmentation with gabapentin during the acute phase of their therapy. Seven of the original 18 patients (39%) have continued to experience benefit from maintenance gabapentin treatment. Only three patients had to discontinue the gabapentin because of side effects. None of the 18 patients experienced an obvious significant adverse drug-drug interaction. Five of the patients discontinued gabapentin because of diminished clinical efficacy after a significant period of positive therapeutic effect. The results of this small open study suggest that gabapentin may be effective as an augmenting agent in the maintenance phase of treatment of some bipolar spectrum patients.


DOI: 10.1016/s0165-0327(98)00198-0

Other references

Gerwins, P.; Fredholm, B.B., 1991: Glucocorticoid receptor activation leads to up-regulation of adenosine A1 receptors and down-regulation of adenosine A2 responses in DDT1 MF-2 smooth muscle cells. The effect of glucocorticoid treatment of DDT1 MF-2 smooth muscle cells on the signaling via two adenosine receptors with opposing actions on cAMP generation was examined. Treatment with dexamethasone caused a dose- and time-dependent increase in...

Long E.O.; Dawid I.B., 1979: Transcription of drosophila melanogaster ribosomal genes. Journal of Supramolecular Structure 8(SUPPL 3): 53

Farrell, S.L.; Laxon, S.W.; McAdoo, D.C.; Yi, D.; Zwally, H.J., 2009: Five years of Arctic sea ice freeboard measurements from the Ice, Cloud and land Elevation Satellite. Using data from the first Earth-orbiting laser altimeter, the Geoscience Laser Altimeter System (GLAS), onboard the Ice, Cloud and land Elevation Satellite (ICESat), we analyze sea ice freeboard in the Arctic Ocean. We describe a new method for se...

Merrick, J., 2000: EDITORIAL: My mother is a teenager. International Journal of Adolescent Medicine and Health 12(4): 259-260

Simms, C., 1973: Goldfinch trapped on burdock. British Birds, 661: 38

Kusumo, S., 1966: The response of soya-bean varieties to photoperiod. Of 15 varieties, Sumbing and 831 proved particularly adapted to Indonesian short-day conditions of 11-12 hours. Ringgit, Gendjah Slawi, Wakashima, 16, Merapi and Biloxi yielded better under long-day photoperiods of 12-13 hours. Davros, 29, 1000, 2...

Russell, H.K., 1972: A modification of Movat's pentachrome stain. Archives of Pathology 94(2): 187-191

Verreault, R.; Semba, R.D.; Volpato, S.; Ferrucci, L.; Fried, L.P.; Guralnik, J.M., 2002: Low serum vitamin D does not predict new disability or loss of muscle strength in older women. To determine whether serum levels of 25-hydroxyvitamin D (25(OH)D) and parathyroid hormone (PTH) predict accelerated decline in muscular strength or onset of new disability in mobility and upper extremity functioning over a 3-year follow-up. A com...

Zgorzalewicz, T.; Kowalska, A., 1971: Results of treatment of cervix uteri carcinoma during 1960-1964. Nowotwory 21(3): 223-228

Rivalin, R.; Lepinoux-Chambaud, C.; Eyer, Jël.; Savagner, Fédérique., 2015: The NFL-TBS.40-63 anti-glioblastoma peptide disrupts microtubule and mitochondrial networks in the T98G glioma cell line. Despite aggressive therapies, including combinations of surgery, radiotherapy and chemotherapy, glioblastoma remains a highly aggressive brain cancer with the worst prognosis of any central nervous system disease. We have previously identified a n...