geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Ophthalmic findings in fetal anticonvulsant syndrome(s)


, : Ophthalmic findings in fetal anticonvulsant syndrome(s). Ophthalmology 109(5): 942-947

Purpose: To report the prevalence of ocular abnormalities in a group of children diagnosed with fetal anticonvulsant (FAC) syndrome(s). Design: Retrospective, observational, noncomparative case series. Participants: Forty-six children, age range 8 months to 16 years 5 months (mean, 7 years 1 month), with a confirmed diagnosis of an FAC syndrome. Thirty-seven subjects were exposed in utero to sodium valproate (29 as monotherapy), and the remainder (n=9) to other anticonvulsants, mainly carbamazepine. Methods: A total of 46 subjects underwent ophthalmic assessment consisting of visual acuity, cover test, ocular movements, analysis of spectacle lens power, cycloplegic refraction, and anterior segment examination with portable slit lamp, plus direct and indirect ophthalmoscopy. Main Outcome Measures: Refraction and ocular motility status. Results: Thirty-one of 46 (67%) had ocular abnormalities, most commonly errors of refraction (19 of 46; 41%). Myopia was common (14 of 28; 50%) in those exposed to valproate monotherapy and there were high frequencies of strabismus (20%), astigmatism (24%), and anisometropia (11%) in the group as a whole. Thirty-one percent of myopes and 27% of astigmates did not wear glasses, of whom three subjects and two subjects, respectively, were less than 8 years old and therefore at risk of anisometropic or ametropic amblyopia. One subject had epicanthus, one color vision deficiency, and one bilateral congenital cataract. Conclusions: We conclude that (1) abnormal ophthalmic findings are common in subjects with confirmed FAC syndrome, in particular myopia in those with fetal valproate syndrome; (2) children with FAC syndrome should receive preschool vision testing; (3) preschool vision testing should be considered in all children exposed to anticonvulsants in utero.

US$19.90

PMID: 11986102

DOI: 10.1016/s0161-6420(02)00959-4


Other references

Duprat F.; Guilbot A., 1975: Solvent vs nonsolvent water in starch alcohol water systems. Duckworth, R B (Ed ) Food Science And Technology Water Relations Of Foods Proceedings Of An International Symposium Glasgow, Scotland, Sept 1974 Xviii+716p Illus Academic Press: London, England; New York, N Y , U S A Isbn 0-12-223150-3 173-182

Troncoso, E.; Rodriguez, M.; Feria, M., 1995: Light-induced arousal affects simultaneously EEG and heart rate variability in the rat. In awaken rats, ECG and EEG were simultaneously analysed in order to quantify the cortical EEG and beat-to-beat heart rate variability (HRV) in response to light onset. The HRV bands LF (40-200 mHz), MF (200-600 mHz) and HF (600-2500 mHz) and the...

Fukutake, K.; Ukita, M., 1968: Preservation of blood platelets. Saishin Igaku. Modern Medicine 23(9): 1994-1995

Tokumaru, M., 1972: Evaluation of clinical training. Nihon Shonika Gakkai Zasshi. Acta Paediatrica Japonica 76(3): 141-143

Kosugi, T.; Matsuo, O.; Mihara, H.; Hirano, K.; Hamaya, M., 1982: Characteristics of tissue plasminogen activator from paranasal mucous membrane in chronic sinusitis. Tissue extract of paranasal mucous membrane from patients with chronic sinusitis was found to show a large lysis area on plasminogen-rich fibrin plates, but not on plasminogen-free fibrin plates. This indicates the existence of tissue plasminogen...

Sarsfield, J.K.; Gowland, G.; Toy, R.; Norman, A.L., 1974: Mite-sensitive asthma of childhood. Trial of avoidance measures. Archives of Disease in Childhood 49(9): 716-721

Ishida, F.; Ito, T.; Takei, M.; Shimodaira, S.; Kitano, K.; Kiyosawa, K., 2000: Genetic linkage of Kozak sequence polymorphism of the platelet glycoprotein Ibalpha with human platelet antigen-2 and variable number of tandem repeats polymorphism, and its relationship with coronary artery disease. The -5 C/T polymorphism of platelet glycoprotein (GP) Ibalpha is a major determinant of the level of GP Ib/V/IX complex surface expression. We investigated the frequency of this polymorphism among Asian populations. The gene frequencies of cytosin...

Burian, K., 1950: Antistin therapy of acute coryza. Wiener Medizinische Wochenschrift 100(43-44): 729-730

Belozerskii, A.N.; Spirin, A.S.; Kudlai, D.G.; Skavronskaia, A.G., 1955: Comparative biochemical and immunologic investigations on directed variability of certain bacteria of the enteric group. Biokhimiia 20(6): 686-695

Lakin, V.V.; Belykh, A.G., 1983: Effect of somatotropic hormone glucagon and insulin on 5' nucleotidase of rat liver cell plasma membranes in vitro. In plasma membranes of rat liver cells in vitro interaction of STH [somatotropic hormone] glucagon, NaF and caffeine with plasma membranes is accompanied by inhibition of 5'-nucleotidase. cAMP inhibited the enzyme. Unlike STH, glucagon, NaF a...