Orally administered clonidine significantly reduces pain during injection of propofol

Yoshikawa, T.; Wajima, Z.; Ogura, A.; Inoue, T.; Ogawa, R.

Yoshikawa, T.; Wajima, Z.; Ogura, A.; Inoue, T.; Ogawa, R., 2001: Orally administered clonidine significantly reduces pain during injection of propofol. British Journal of Anaesthesia 86(6): 874-876

We examined the analgesic effects of orally administered clonidine on pain induced by injection of propofol (Diprivan; 2,6-diisopropyl phenol). Female patients (n=81) were randomly allocated to one of two groups: oral clonidine (5.5 microg kg(-1)) followed by i.v. propofol and a control group given placebo followed by i.v. propofol. The median pain score in the group receiving clonidine, using a four-point scale (0=no pain, 1=minimal pain, 2=moderate pain, 3=severe pain) was 1 (0-2), significantly lower than in the control group [2 (1-3), median (25-75 percentiles), P<0.001].

PMID:

11573599

DOI:

10.1093/bja/86.6.874

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