geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Ovarian hyperstimulation syndrome-model rats; the manifestation and clinical implication


, : Ovarian hyperstimulation syndrome-model rats; the manifestation and clinical implication. Molecular & Cellular Endocrinology 202(1-2): 47-52, April 28

Ovarian hyperstimulation syndrome (OHSS) is the most serious complication of ovulation induction with the gonadotropins. Though vascular endothelial growth factor (VEGF) has been implicated as a prime causative factor of OHSS progression, other factors must also be involved in the pathogenesis of OHSS. We have established an experimental model of OHSS in immature female rats. The ovarian weights and vascular permeability of the OHSS model rats are significantly increased by the ovarian stimulation with human chorionic gonadotropin (hCG). hCG elicits VEGF production in OHSS model rat ovaries. The addition of potent synthetic progesterone antagonist RU486, which reduces the extension of OHSS, attenuates the ovarian kinin and VEGF production dose-dependently whereas the VEGF gene expression was stable. VEGF protein detected in both the lung and the liver of the OHSS model rats is not affected at 24 h after the addition of hCG and RU486 in contrast to the ovary. Our results demonstrate that progesterone is implicated in the development of OHSS, in part, to enhance the ovarian VEGF production by post-transcriptional and organ-specific control.

US$19.90

PMID: 12770729

DOI: 10.1016/s0303-7207(03)00061-3


Other references

Foelix, RF., 1988: Menschen und Spinnen. Bulletin de la Societe Fribourgeoise des Sciences Naturelles, 771-2: 5-16

Orlik, Błomiej.; Madej, Pł.; Owczarek, A.; Skałba, P.; Chudek, J.; Olszanecka-Glinianowicz, M., 2015: Plasma omentin and adiponectin levels as markers of adipose tissue dysfunction in normal weight and obese women with polycystic ovary syndrome. It is suggested that disturbed adipokines release plays a role in PCOS pathogenesis. The aim of this study was to assess plasma levels of omentin and adiponectin as well as the omentin to adiponectin ratio, as markers of adipose tissue dysfunction...

Wiesli, P.; Schmid, C., 2001: Hyper- and hypothyroidism: which tests are reliable in general practice?. Thyroid function is evaluated by measuring the serum concentrations of thyroid stimulating hormone (TSH) and free thyroxine (fT4). To confirm a normal thyroid function, a TSH within the normal range is usually sufficient. If hyperthyroidism or hyp...

Morse, C.A.; Buist, A.; Durkin, S., 2000: First-time parenthood: influences on pre- and postnatal adjustment in fathers and mothers. The objective of the study was to examine moods and adjustment through the transition to parenthood as an issue affecting the couple; to examine not only the postpartum but also the pregnancy experience and to explore how each partner's exper...

Duncan G.W.; Hilton E.J.; Kreager P.; Lumsdaine A.A., 1973: Proceedings of a workshop on the introduction of fertility control methods seattle washington usa december 4 6 1972. Duncan, Gordon W Et Al (Ed ) Fertility Control Methods Strategies For Introduction Proceedings Of A Workshop Seattle, Washington, U S A , Dec 4-6, 1972 Xiii+230p Illus Academic Press: New York, N Y , U S A , London, England 1-230

Jonsson, B.; Lukiansk, M., 1963: Systemic arterial pressure during exercise in patients with pulmonary hypertension. In primary pulmonary hypertension the systemic arterial pressure decreases during the first minute of work. This is not seen in patients with high pulmonary vascular resistance associated with a patent ductus arteriosus or mitral stenosis. The imp...

D.Assis, Arlindo, 1939: A proposito da transformacao dos tipos do bacilo de Koch. The "Ratti" culture appeared. in work of A. Boquet, to have changed from the human to the bovine type.- A culture maintained 12 yrs. in Brazil was still of the human type. Rabbit expts. are descr.

Halim, N.A., 1988: A check list of nematode and host in Malaysia. A list of 46 plant parasitic nematode species in 27 genera and their associated hosts in Malaysia is given.

Rod Emile, 1982: Tectonic setting of ophiolite obduction in Oman. JGR Journal of Geophysical Research

Sharykin, A.S., 1981: Prostaglandins and the treatment of congenital heart defects. Pediatriia: 66-68