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Overexpression of interleukin-15 protects against Escherichia coli-induced shock accompanied by inhibition of tumor necrosis factor-alpha-induced apoptosis


, : Overexpression of interleukin-15 protects against Escherichia coli-induced shock accompanied by inhibition of tumor necrosis factor-alpha-induced apoptosis. Journal of Infectious Diseases 187(9): 1442-1451

Interleukin (IL)-15, a potent inhibitor of tumor necrosis factor (TNF)-alpha-mediated apoptosis, causes multiple organ failure during endotoxic shock. We investigated the potential role of IL-15 in protection against Escherichia coli-induced shock by using IL-15 transgenic (Tg) mice. These mice were resistant to an otherwise lethal challenge with E. coli, although bacterial burden and serum levels of TNF-alpha were similar in non-Tg mice. Apoptosis in cells of the peritoneal cavity, liver, spleen, or lung was significantly suppressed in IL-15 Tg mice after E. coli infection. Peritoneal cells from naive IL-15 Tg mice were also resistant to TNF-alpha-induced apoptosis in vitro, and neutralization of endogenous IL-15 significantly aggravated TNF-alpha-induced apoptosis. Exogenous IL-15 prevented TNF-alpha-induced apoptosis in normal mice in vitro and improved the survival rate after E. coli challenge. These results suggest that IL-15 overexpression can prevent TNF-alpha-induced apoptosis and protect against E. coli-induced shock, indicating a possible therapeutic application of IL-15 for septic shock.

US$19.90

PMID: 12717626

DOI: 10.1086/374643


Other references

More, P.K., 1991: 12.5 fibre pol 2.0 imbibition per fibre reduced mill loss, stabilised. Noel Deerr's '12.5% fibre reduced' and B.L. Mittal's 'whole reduced' mill extraction equations are used as indicators of milling performance, but the further the composition of cane differs from standard pol and fibre...

Lipsett, M.B., 1973: Benign masculinizing adrenal adenomas. New England Journal of Medicine 289(15): 802-803

Ahmed, S.F.; Cheng, A.; Dovey, L.; Hawkins, J.R.; Martin, H.; Rowland, J.; Shimura, N.; Tait, A.D.; Hughes, I.A., 2000: Phenotypic features, androgen receptor binding, and mutational analysis in 278 clinical cases reported as androgen insensitivity syndrome. Androgen insensitivity syndrome (AIS) is the most common single entity that results in male under-masculinization, but large cohort studies of AIS have rarely been performed. Over the last decade, nationwide cooperation between pediatric endocrino...

Milne, M.I.; Younger, E.R., 1947: Relief of pain in childbirth. British Medical Journal 2(4513): 16-16

Glaser R.; Kiecolt Glaser J.K.; Speicher C.E.; Holliday J.E., 1985: Stress loneliness and changes in herpesvirus latency. Tihs study used a prospective design to examine the influence of examination stress and loneliness on herpesvirus latency as measured by changes in antibody levels to three herpesviruses, Epstein-Barr virus (EBV), Herpes simplex type I (HSV-1), an...

Bode, L.; Pocchiari, M.; Gelderblom, H.; Diringer, H., 1985: Characterization of antisera against scrapie-associated fibrils (SAF) from affected hamster and cross-reactivity with SAF from scrapie-affected mice and from patients with Creutzfeldt-Jakob disease. Antisera prepared in rabbits and, for the first time in mice, against scrapie-associated fibril (SAF) protein from hamster brain were measured by a modified ELISA (NC-ELISA) and used for a detailed analysis of SAF proteins from hamsters, mice, and...

Kobayashi, K.; Taguchi, M.; Seto, K.; Shimada, T., 1993: Differentiation of cholera-enterotoxin producing Vibrio strains by polymerase chain reaction. The pathogenic factor of Vibrio cholerae that induces a severe watery diarrhea in humans is cholera enterotoxin (CT). We have earlier reported on the use of a specific polymerase chain reaction method (PCR) for confirmation of CT-production. In ou...

Hasansulama, M., 1973: Socio-economic background and problems of agro-technical development work in the Indonesian Bandung region. Experience of the "Panca-Usaha" information programme is used to illustrate the problems arising in the introduction and diffusion of agro-technical innovations. Information is presented on which factors encourage or discourage adoption...

Friant, M., 1948: La morphologic originelle dos inoisives : son importance en systematique ohez les Soricidae (MuBaraignes) d'Europe. Revue de Stomatologie Paris, 49: 115-117

Anonymous, 2011: Extreme 21 Russian fires and Pakistan floods linked meteorologically. Two of the most destructive natural disasters of 21 were closely linked by a single meteorological event, even though they occurred 1,5 miles (2,414 km) apart and were of completely different natures, a new NASA study suggests.