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Paracrine regulation of matrix metalloproteinase expression in the normal human endometrium

, : Paracrine regulation of matrix metalloproteinase expression in the normal human endometrium. Gynecologic and Obstetric Investigation 48 Suppl 1: 2-13

Endometrial expression of matrix metalloproteinase (MMP)-3, MMP-7 and MMP-11 occurs during menstrual breakdown and subsequent estrogen-mediated growth, but not during the secretory phase. These enzymes are suppressed by progesterone treatment. Paracrine factors, including transforming growth factor-beta (TGF-beta) and retinoic acid, are also critical for MMP regulation in the endometrium. In contrast, inflammatory cytokines such as interleukin-1alpha may block or interfere with steroid-mediated MMP regulation at ectopic sites of growth. Using in vitro models, our laboratory has investigated the complex interactions between progesterone and locally produced cytokines that may affect MMP expression during the development of endometriosis. Our results indicate that targeting the regulation of MMPs may represent an appropriate therapeutic strategy for the treatment of endometriosis. Copyrightz1999S. KargerAG,Basel


PMID: 10559659

DOI: 52863

Other references

Zhou, X.-Hong; Shi, H.-Chang; Yu, T., 2008: Characterization of a spherical packing medium for biological nitrogen removal by microelectrodes. w A novel packing medium comprised of a spherical net-like shell, plastic stuffing, and a perforated hollow duct for biological reactors was investigated. In this study, we examined a biofilm process that employed the packing medium for combined...

Matsubara K.; Matsuda J., 1990: Ne enrichment in tektites and experiment of Ne diffusion into silica glass. Papers Presented to the

Horton, J.R.; Liu, X.; Gale, M.; Wu, L.; Shanks, J.R.; Zhang, X.; Webber, P.J.; Bell, J.S.K.; Kales, S.C.; Mott, B.T.; Rai, G.; Jansen, D.J.; Henderson, M.J.; Urban, D.J.; Hall, M.D.; Simeonov, A.; Maloney, D.J.; Johns, M.A.; Fu, H.; Jadhav, A.; Vertino, P.M.; Yan, Q.; Cheng, X., 2016: Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. The KDM5/JARID1 family of Fe(II)- and α-ketoglutarate-dependent demethylases removes methyl groups from methylated lysine 4 of histone H3. Accumulating evidence supports a role for KDM5 family members as oncogenic drivers. We compare the in vitr...

Boerner P.; Breitbart M.; Mason T., 1976: Pathways of mitochondrial biogenesis in temperature sensitive mutants of yeast. Federation Proceedings 35(7): 249

Ramsden, C.T., 1918: Vita y exploraciones zoologicas del Dr. Juan Grundlach en Cuba (1839-1896). Habana Mem Soc Cubana Hist Nat, 3 146-168)

Zhang, J.; Feider, C.L.; Nagi, C.; Yu, W.; Carter, S.A.; Suliburk, J.; Cao, H.S.Tran.; Eberlin, L.S., 2017: Detection of Metastatic Breast and Thyroid Cancer in Lymph Nodes by Desorption Electrospray Ionization Mass Spectrometry Imaging. Ambient ionization mass spectrometry has been widely applied to image lipids and metabolites in primary cancer tissues with the purpose of detecting and understanding metabolic changes associated with cancer development and progression. Here, we r...

Phelan, K.; McDermid, H.E., 2012: The 22q13.3 Deletion Syndrome (Phelan-McDermid Syndrome). The 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome, is a contiguous gene disorder resulting from deletion of the distal long arm of chromosome 22. In addition to normal growth and a constellation of minor dysmorphic features, th...

Al-Kahtani, M.A.; Youssef, A.M.; Fathi, A.A., 2009: Ecological studies on Al-Khadoud Spring, Al-Hassa, Saudi Arabia. Al-Khadoud spring is one of the most important water resources in Al-Hassa Governorate, Saudi Arabia. However, much of its biotic information is still unknown. This study presented preliminary ecological information of this aquatic body. Regarding...

Sivit, C.J.; Nussbaum Blask, A.R.; Bulas, D.I., 1993: Pediatric pelvic sonography. Ultrasound Quarterly 11(1): 59-93

Ashriatova, N.Kh., 1989: Establishing the maximum permissible level of methylnitrophos in atmospheric air. Gigiena i Sanitariia: 77-79