+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Platelets and restenosis

, : Platelets and restenosis. Journal of the American College of Cardiology 35(3): 555-562, March 1

Restenosis is currently the major limitation of percutaneous transluminal coronary angioplasty (PTCA). Factors such as elastic recoil, migration of vascular smooth muscle cells from media to intima, neointimal proliferation and vascular remodeling underly the restenotic process. Presently there is no effective therapy available for restenosis. The role of platelets in the development of thrombosis and abrupt closure after PTCA is well recognized. However, the effects of platelets in PTCA extend well beyond the early phase. Although antiplatelet agents such as glycoprotein IIb/IIIa antagonists have been reported to reduce target vessel revascularization, major unresolved controversies still exist. This report reviews the potential role of platelets in restenosis. Various drugs, successfully tested in experimental studies and in a small number of human studies, that inhibit the effect of platelets on the restenotic process are also reviewed.


PMID: 10716455

DOI: 10.1016/s0735-1097(99)00596-3

Other references

Hayashida, N., 2016: Non-Hsp genes are essential for HSF1-mediated maintenance of whole body homeostasis. Mammalian tissues are always exposed to diverse threats from pathological conditions and aging. Therefore, the molecular systems that protect the cells from these threats are indispensable for cell survival. A variety of diseases, including neurod...

Bátai, I.; Kerényi, M.; Falvai, J.; Szabó, G., 2002: Bacterial growth in ropivacaine hydrochloride. Drugs affecting bacterial growth may influence the occurrence of postoperative infections. Ropivacaine 10 mg/mL killed Staphylococcus aureus and Escherichia coli; ropivacaine 2 mg/mL supported the growth of E. coli.

Mia, A.S.; Kravcak, D.M.; Cassell, G.H., 1981: Detection of Mycoplasma pulmonis antibody in rats and mice by a rapid micro enzyme linked immunosorbent assay. Laboratory Animal Science 31(4): 356-359

Brock, Kenneth J., 1998: The migration season: August 1-November 30, 1997. Middlewestern Prairie Region. Field Notes 52(1): 66-71

Wayand, W., 1984: Pancreatic duct occlusion. Experimental studies and clinical application. After Whipple's procedure or pancreatic transplantation complications may be caused by the persistance of the exocrine function. Since 1978 pancreatic duct occlusion with prolamin ("Ethibloc") has been performed occasionally to elim...

Hoff, J.H., 1901: Physical Chemistry. Science 14(343): 126-129

Gilloteaux, J.; Steggles, A.W., 1985: Endometrium cell surface abnormalities in the Syrian hamster as a result of in utero exposure to diethylstilbestrol. Scanning electron microscopy (SEM) was used to observe changes in the hamster endometrium cell surface following in utero pre- and/or postnatal exposure to diethylstilbestrol (DES). Some of the changes in cell surfaces are associated with alterati...

Kario, K.; Hoshide, S.; Nakagawa, Y.; Shimada, K., 1998: Cerebral haemorrhage triggered by calcium antagonist. Journal of Human Hypertension 12(2): 143-144

Jeannin, J-Michel., 2013: Society bulletins. Forschende Komplementarmedizin 19(3): 165-167

Anonymous, 1918: Ticks On the Run in Louisiana. According to Dr. E. T. Smith in charge of tick eradication in Louisiana, the total number of cattle dippings in August was 2.113.386; 84, 461 horses and mules were inspected and 32, 188 were dipped.