geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Polymorphism around cog extends into adjacent structural genes


, : Polymorphism around cog extends into adjacent structural genes. Current Genetics 35(6): 631-637, July

The recombination hotspot cog overlaps a highly polymorphic 950-bp region of linkage group I in Neurospora crassa. The sequence of this region in the four strains, Lindegren 25a, Lindegren A, Emerson A and St. Lawrence 74A, each differs from the others by 1.4% or more. Comparison of the sequence of St. Lawrence 74A and Lindegren 25a each side of cog shows a high level of sequence heterology extending in both directions, including the coding sequences for his-3 and a putative gene lpl with homology to yeast lysophospholipase. The St. Lawrence 74A and Lindegren 25a sequences of his-3, centro-mere-proximal to cog, differ at 14 nucleotides, resulting in six amino-acid variations between the predicted protein sequences. In lpl, distal from cog, the sequences differ at 19 nucleotides leading to five amino-acid differences between the predicted proteins. Sequence heterology between St. Lawrence 74A and Lindegren 25a peaks either side of cog and then declines with distance. At the am locus on linkage group V, heterology is much less but peaks close to a weak recombination hotspot 5' of the coding sequence. Uneven distribution of polymorphism along chromosomes has been explained by a hitch-hiking hypothesis in which selection for advantageous mutations causes local fixation of unselected variation. We suggest that new mutations arising from errors in recombination also contribute to the uneven distribution of polymorphism.

US$19.90

PMID: 10467008

DOI: 10.1007/s002940050462


Other references

Andriyashev, A.P.; Chernova, N.V., 1997: Two new liparid fish species (Liparidae, Scorpaeniformes) from abyssal depths of the northeastern Atlantic. Two new liparid fish species are described from the depth of about 4,000 meters in northeastern Atlantic (depression to the south of Porcupine seabight): Careproctus aciculipunctatus sp.n. and Paraliparis abyssorum sp.n. The former is most close t...

Petrov, E.E., 1996: The antioxidant allowance of the body and lipid peroxidation in patients with gastric and duodenal peptic ulcers. Likars'ka Sprava: 13-18

Guevara-Franco, Jé.Alfredo.; Alonso-Calleja, C.; Capita, R., 2010: Aminopeptidase activity by spoilage bacteria and its relationship to microbial load and sensory attributes of poultry legs during aerobic cold storage. The shelf life of poultry legs stored aerobically and the possible role of the aminopeptidase activity of gram-negative bacteria (p-nitroaniline test) as a predictor of poultry spoilage were evaluated on the basis of microbiological and sensory pa...

Li, J.Y.; Kang, Z.S.; Shen, Q.Y.; Wei, G.R., 1995: Ultrastructural study on the effects of seed coat formulation No. 17 on wheat stripe rust development in host wheat. Seedlings from seed coated with SCF No. 17 (containing the fungicide triadimenol) were inoculated with a virulent race of Puccinia striiformis and the subsequent development of the pathogen examined by EM. A series of changes included in the host...

Capska Y.; Kalifat R., 1979: Malignant lymphomas of the digestive tract in sfax tunisia. Laboratory Investigation 40(2): 244

Geil, P., 2010: Diabetes nutrition bars and shakes. What can they do for you?. Diabetes Self-Management 27(1): 40, 42, 44-6

Levnajić, Z.; Tadić, B., 2011: Stability and chaos in coupled two-dimensional maps on gene regulatory network of bacterium E. coli. The collective dynamics of coupled two-dimensional chaotic maps on complex networks is known to exhibit a rich variety of emergent properties which crucially depend on the underlying network topology. We investigate the collective motion of Chirik...

Giosué, S.; Casarini, M.; Alemanno, L.; Galluccio, G.; Mattia, P.; Pedicelli, G.; Rebek, L.; Bisetti, A.; Ameglio, F., 1998: Effects of aerosolized interferon-alpha in patients with pulmonary tuberculosis. Interferon-alpha (IFN-alpha) is a cytokine exerting pleiotropic activities, including antimicrobial effects, especially directed against intracellular infectious bacteria. It may be administered by aerosol to reach the lower respiratory tract with...

Carlson, D.; Fernandez, J.A.; Poulsen, H.D.; Nielsen, B.; Jacobsen, S-E., 2012: Effects of quinoa hull meal on piglet performance and intestinal epithelial physiology. Saponin-containing feed additives have shown positive effects on pig performance. Quinoa hull has high saponin content and may be of interest as a feed additive. This study aimed to evaluate quinoa hull meal (QHM) as a feed additive in a pig diet....

Dulos, J.; Wijnands, F.P.G.; van den Hurk-van Alebeek, J.A.J.; van Vugt, M.J.H.; Rullmann, J.A.C.; Schot, J-J.G.; de Groot, M.W.G.D.M.; Wagenaars, J.L.; van Ravestein-van Os, R.; Smets, R.L.; Vink, P.M.; Hofstra, C.L.; Nelissen, R.L.H.; van Eenennaam, H., 2013: p38 inhibition and not MK2 inhibition enhances the secretion of chemokines from TNF-α activated rheumatoid arthritis fibroblast-like synoviocytes. For many years the p38 MAP kinase (MAPK) has been a major anti-inflammatory target for the development of an oral therapy for rheumatoid arthritis (RA). However, disappointing results from Phase II clinical studies suggest that adaptations may occ...