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Polymorphisms of apolipoprotein E and H in Korean population: Confirming the distribution of APOH*3Kongju allele


, : Polymorphisms of apolipoprotein E and H in Korean population: Confirming the distribution of APOH*3Kongju allele. Korean Journal of Genetics 21(2): 89-95, June

In order to identify the detailed distributions of genetic variants of apolipoprotein E and H which were reported to be first observed variants in Kongju population of Korea, we have screened a large number of samples from Korean populations. As a result, we could not identified a variant allele (APOE*V), which was observed in Kongju population, except three common alleles for the APOE. The frequencies of the APOE*2, APOE*3 and APOE*4 alleles were 0. 069, 0. 828 and 0. 103, respectively. However, we have discovered a variant allele (APOH*3Kongju), which was first observed in Kongju, except three common alleles for the APOH in this study. The frequencies of the APOH*1, APOH*2, APOH*3 and APOH*3Kongju alleles were 0.012, 0.909, 0.074 and 0.005, respectively. Also, APOH*3Kongju was showed the reactivity of mAb 3D11. All samples carrying APOH*3 and APOH*3Kongju alleles appeared to be APOH 3W subtype in Korean population.

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