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Predictive value of systolic and diastolic function for incident congestive heart failure in the elderly: The Cardiovascular Health Study

, : Predictive value of systolic and diastolic function for incident congestive heart failure in the elderly: The Cardiovascular Health Study. Journal of the American College of Cardiology 37(4): 1042-1048, March 15

OBJECTIVES: We sought to assess the ability of echocardiographic indices of systolic and diastolic function to predict incident congestive heart failure (CHF). BACKGROUND: Noninvasive indices of subclinical systolic and/or diastolic dysfunction that can be used to identify patients in a transition phase between normal cardiac function and clinical CHF would be valuable. Though midwall shortening and Doppler mitral inflow patterns are seemingly well suited to predict subsequent CHF, the predictive value of these indices has not been investigated. METHODS: We studied 2,671 participants in the Cardiovascular Health Study who were free of coronary heart disease, CHF or atrial fibrillation. Clinical and quantitative echocardiographic data were obtained in all participants. RESULTS: At a mean follow-up of 5.2 years (range 0 to 6 years), 170 participants (6.4% of the cohort) developed CHF. Although 96% of these participants had normal or borderline ejection fraction (EF) at baseline, only 57% had normal or borderline EF at the time of hospitalization. In multivariate modeling, fractional shortening at the endocardium (relative risk (RR) 1.85 per 10-unit decrease, confidence interval (CI) 1.27 to 2.39), fractional shortening at the midwall (RR 1.29 per five-unit decrease, 95% CI 1.11-1.51) and peak Doppler peak E (RR 1.15 for each 0.1 M/s increment; CI 1.02 to 1.21) independently predicted incident CHF. Both high and low Doppler E/A ratios were predictive of incident CHF. CONCLUSIONS: Roughly half the occurrences of CHF in this population are associated with normal or borderline EF. Echocardiographic findings suggestive of subclinical contractile dysfunction and diastolic filling abnormalities are both predictive of subsequent CHF. The standard (FSendo) and refined (FSmw) parameters of systolic function performed similarly in this regard, though subjects with left ventricular hypertrophy and depressed FSmw are at particularly high risk for subsequent CHF.


PMID: 11263606

DOI: 10.1016/s0735-1097(01)01110-x

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C.P.Dopazo, B.Lupiani, J.L.Barja, S.K.Samal, E.M.Hetrick, 1990: Cell line susceptibility to five fish rota viruses. The infectivity of five recently isolated fish rotaviruses (TRV, ASR, HBR, SBR and SRV) for fish (CHSE-214, EPC, FHM and BB) and 2 mammalian (MA 104 and MDBK) cell lines was assayed at different temperatures. None of the viruses produced CPE in ei...

Tajima, S.; Hironaka, M.; Oshikawa, K.; Bando, M.; Ohno, S.; Saito, K.; Sohara, Y.; Sugiyama, Y., 2005: Intrathoracic sporadic desmoid tumor with the beta-catenin gene mutation in exon 3 and activated cyclin D1. We report a case of intrathoracic desmoid tumor without familial adenomatous polyposis and demonstrate beta-catenin mutation of exon 3. A 15-year-old male presented with a desmoid tumor after having sustained an assault. In an examination for a mu...

Tang, B.; Yuan, H.; Cheng, L.; Zhou, X.; Huang, X.; Li, J., 2015: Effects of gallic acid on the morphology and growth of hydroxyapatite crystals. This study was designed to explore the effect of gallic acid (GA, one of the ingredients of chemical compounds from galla chinensis) on the morphology and growth of hydroxyapatite crystals. The crystals was produced by mixing CaCl2 and KH2PO4 with...

Guo, X.H.a; Gallagher, M.; Polonieki, J.; Camm, J., 2004: Ventricular pauses during atrial fibrillation predict relapse after external electrical cardioversion A prospective Study. Journal of the American College of Cardiology 43(5 Supplement A): 120A, March 3

Kohno, S.; Nakao, S.; Ogawa, K.; Yamamura, H.; Nabe, T.; Ohata, K., 1994: Possible participation of histamine H3-receptors in the regulation of anaphylactic histamine release from isolated rat peritoneal mast cells. Anaphylactic histamine release from isolated rat peritoneal mast cells was concentration-dependently blocked by a 5-min treatment with exogenous histamine at 0.9 and 9 microM and enhanced by a 20- to 30-min treatment with thioperamide (H3-antagoni...

Verpoorte, R.; Siwon, J.; Essen, G.F.A.V.n; Tieken, M.; Svendsen, A.B., 1982: Studies on Indonesian medicinal plants. VII. Alkaloids of Arcangelisia flava. Six quaternary alkaloids, thalifendine, dehydrocorydalmine, jatrorrhizine, pycnarrhine, berberine and palmatine, and 3 tertiary alkaloids, hydroxy-berberine, limacine and homoaromoline were isolated from stems and roots of A. flava. [For part VI s...

Sahay, M.; Swain, M.; Padua, M., 2013: Renal cortical necrosis in tropics. The aim of this study is to review cases of renal cortical necrosis (RCN) that were seen on renal biopsy at our center over a period of seven years. All renal biopsy records over seven years at the Osmania General Hospital were reviewed to identif...

Yang, Z-Tian.; Shen, W.; Deng, J-Xian., 2004: Nuclear reprogramming of somatic nuclear transfer embryos. Although the cloned animals have been successfully generated in a number of mammalian species, there are still many problems about this technology. The developmental aberrancies include a high rate of abortion during early gestation and high rate...

Shute, N., 2007: Violence interrupted. U.S. News & World Report 140(22): 67-68

Merrill, E.D., 1943: An attempt to complete the rec-ord. Discussion of 20 names of species from Boldingh's Zakflora voor de Landbouwst-reken op Java, mostly new combinations lacking proper citations.