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Prevalence et valeur pronostique des anticorps seriques anti-p53 au cours du carcinome hepatocellulaire: Etude chez 159 malades


, : Prevalence et valeur pronostique des anticorps seriques anti-p53 au cours du carcinome hepatocellulaire: Etude chez 159 malades. Gastroenterologie Clinique et Biologique 24(12): 1159-1163

Objectives: Genetic alterations in the p53 protein may induce serum anti-p53 antibodies. The aim of this study was to assess the prevalence of serum anti-p53 antibodies in a large series of Western patients with hepatocellular carcinoma and the pronostic value of these antibodies on survival. Methods: Serum anti-p53 antibodies were assayed in 159 patients with hepatocellular carcinoma, at diagnosis, using an immunoenzymatic method.

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