+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Quantitative testing of liver function in patients with cirrhosis due to chronic hepatitis C to assess disease severity

, : Quantitative testing of liver function in patients with cirrhosis due to chronic hepatitis C to assess disease severity. Liver 21(1): 26-30, Feb

Background/Aims: Quantitative testing of liver function (QTLF) may allow a prognostic assessment of patients with various liver diseases. However, there are insufficient data about patients with liver cirrhosis due to hepatitis C. Patients/Methods: 86 consecutive patients (58 males, 28 females, age: 48.3 +- 11.7 years) with chronic hepatitis C (HCV RNA pos.) underwent sonographically guided liver biopsy to confirm the diagnosis of cirrhosis. QTLF included aminopyrine breath test (microsomal liver function), galactose elimination capacity (cytosolic liver function), sorbitol clearance (liver plasma flow) and indocyanine green clearance (liver perfusion). Values were correlated with the Child-Pugh classification. Results: 55% of the patients (n=47) had cirrhosis of Child-Pugh grade A, 28% of grade B (n=24) and 17% of grade C (n=15). QTLF showed a steady decrease from Child-Pugh grade A to grade B and to grade C. Contrary to markedly reduced tests of metabolic liver function in Child-Pugh grade patients, surrogate tests of hepatic perfusion were at the lower normal limit. All QTLF were significantly reduced in Child-Pugh grade B and C patients compared to healthy controls. Differences between the three Child grades were significant. Conclusion: In patients with cirrhosis due to hepatitis C, QTLF correlated inversely with Child-Pugh grades. Since in cirrhosis of grade A, surrogate tests of hepatic perfusion remained at the lower normal limit, whereas those of metabolic function were decreased, QTLF may be a tool to predict prognosis or complications in early cirrhosis due to chronic hepatitis C.


PMID: 11169069

DOI: 10.1034/j.1600-0676.2001.210104.x

Other references

Ali, S.; Sun, T.; Narukar, L., 1993: Oligoclonal banding in cerebrospinal fluids of Lyme disease patients. American Journal of Clinical Pathology 100(3): 335

Kireeva S.G.; Selitskaya R.P., 1982: Therapeutic pathomorphosis the influence of the immuno stimulator levamisole on the morphology of specific experimental inflammation. When levamisole was added to the antituberculosis therapy of rabbits with destructive pulmonary tuberculosis, intensive infiltration of the zone of lesions with polymorphonuclear cells and their accumulation in cavities, increased numbers of giant...

Ramsdell, Dc, 1995: Winter air-blast sprayer applications of benomyl for reduction of Eutypa dieback disease incidence in a Concord grape vineyard in Michigan. The efficacy of closely managed pruning and winter air-blast spraying of mature Concord grapevines with benomyl or benomyl plus oil for control of Eutypa dieback disease caused by Eutypa lata was evaluated in a commercial-scale test plot. Three pr...

Wormal, Je, 1992: What to do when handling body fluids. B Wyoming Agricultural Experiment Station: 92 (970)

Watanabe, T.; Fukuzawa, K.; Shibata, H., 2016: Short-Term Response of Sasa Dwarf Bamboo to a Change of Soil Nitrogen Fertility in a Forest Ecosystem in Northern Hokkaido, Japan. In forest ecosystems, a change of soil nitrogen (N) cycling after disturbance is regulated by various factors. Sasa dwarf bamboo (hereafter referred to as Sasa) is an understory plant that grows thickly on the forest floor in northern Hokkaido, Ja...

Becker, U.; Glasser, W.G., 1999: Self-assembly behavior of fluorine-containing cellulose esters. Abstracts of Papers American Chemical Society 217(1-2): BTEC 027

Anonymous, 2012: First evaluation of the Clean Water Acts effects on coastal waters reveals major successes. Levels of copper, cadmium, lead and other metals in Southern California's coastal waters have plummeted over the past four decades, which USC researchers attribute to sewage treatment regulations that were part of the Clean Water Act of 1972...

Törnros, J., 1995: Effect of driving speed on reaction time during motorway driving. Effects of driving speed (70, 90 and 110 km/h) on subsidiary auditory reaction time were studied during car driving on a motorway with a speed limit of 110 km/h. Driving distance was held constant at about 200 km. Twenty-four subjects participated...

Knowles, F., 1965: The action of a neurohypophysial hormone in an elasmobranch fish. Mechanisms of hormone action 129-130

Furth, J.; Haran, G.Era, N.; Curtis, H.J.; Buffett, R.F., 1959: Studies on the pathogenesis of neoplasms by ionizing radiation. I. Pituitary tumors. Cancer Research 19(5): 550-556