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Recurrent hypoxic exposure and reflex responses during development in the piglet


, : Recurrent hypoxic exposure and reflex responses during development in the piglet. Respiration Physiology 123(1-2): 51-61, October

The effects of recurrent hypoxia on cardiorespiratory reflexes were characterized in anesthetized piglets at 2-10 d (n = 15), 2-3 weeks (n = 11) and 8-10 weeks (n = 8). Responses of phrenic and hypoglossal electroneurograms (ENGphr and ENGhyp) to hypoxia (8% 02, bal N2, 5 min), hypercapnia (7% CO2 bal O2, 5 min) and intravenous capsaicin were tested before and after recurrent exposure to 11 episodes of hypoxia (8% O2 bal N2, 5 min). In piglets 2-10 d, ENGphr response to hypoxia declined in proportion to the number of hypoxic exposures; however, ENG hyp response to hypoxia was unchanged. In piglets at 2-10 d, intracisternal injection of bicuculline (GABAA receptor antagonist) reversed effects of recurrent hypoxia on ENGphr hypoxic response, eliminated apnea during hypoxia, as well as the delay in appearance of ENGphr after hypoxia. The ENGphr response to 7% CO2 inhalation also decreased after recurrent hypoxia; however, the ENGphr response to C-fiber stimulation by capsaicin was unaltered. Piglets at 2-3 and 8-10 weeks were resistant to the depressive effects of recurrent hypoxia on respiratory reflex responses. We conclude that the response of the anesthetized newborn piglet to recurrent hypoxia is dominated by increasing inhibition of phrenic neuroelectrical output during successive hypoxic exposures. Central GABAergic inhibition may contribute significantly to the cumulative effects of repeated hypoxia in the newborn piglet experimental model.

US$19.90

PMID: 10996187

DOI: 10.1016/s0034-5687(00)00149-3


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