geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Regional differences in serotonergic input to canine parasternal intercostal motoneurons


, : Regional differences in serotonergic input to canine parasternal intercostal motoneurons. Journal of Applied Physiology 88(5): 1581-1589

There is a mediolateral gradient in activation of the parasternal intercostal (PI) muscle during inspiration. In the present study, we tested the hypotheses that serotonergic [5-hydroxytryptamine (5-HT)] input from descending central drive and/or intrinsic size-related properties of PI motoneurons leads to the differential activation of PI muscles. In dogs, PI motoneurons innervating the medial and lateral regions of the PI muscles at the T(3)-T(5) interspaces were retrogradely labeled by intramuscular injection of cholera toxin B subunit. After a 10-day survival period, PI motoneurons and 5-HT terminals were visualized by using immunohistochemistry and confocal imaging. There were no differences in motoneuron morphology among motoneurons innervating the medial and lateral regions of the PI muscle. However, the number of 5-HT terminals and the 5-HT terminal density (normalized for surface area) were greater in motoneurons innervating the medial region of the PI muscle compared with the lateral region. These results suggest that differences in distribution of 5-HT input may contribute to regional differences in PI muscle activation during inspiration and that differences in PI motoneuron recruitment do not relate to size.

US$29.90

PMID: 10797116


Other references

Marks, D.E.; Wilde, G.R.; Ostrand, K.G.; Zwank, P.J., 2001: Foods of the smalleye shiner and sharpnose shiner in the upper Brazos River, Texas. Digestive tract contents from 486 smalleye shiner Notropis buccula and 475 sharpnose shiner N. oxyrhynchus collected from the upper Brazos River, Texas, during January through December 1998 were examined. Both species are generalist feeders, with...

Shibamoto T.; Kobayashi T.; Kubo K.; Nagata T., 1987: Electron microscopic studies on changes in the alveoli of paraquat administered sheep with special reference to the relationship between lung lymph dynamics and ultrastructure. We studied the ultrastructure of the lung of four sheep after an infusion of paraquat (30 mg/kg) to relate lung vascular changes and lung neutrophils to lung lymph responses. The damage to the alveolar type 1 epithelial cell and alveolar endotheli...

Teoh, E.J.; McGowan, D.R.; Macpherson, R.E.; Bradley, K.M.; Gleeson, F.V., 2015: Phantom and Clinical Evaluation of the Bayesian Penalized Likelihood Reconstruction Algorithm Q.Clear on an LYSO PET/CT System. Q.Clear, a Bayesian penalized-likelihood reconstruction algorithm for PET, was recently introduced by GE Healthcare on their PET scanners to improve clinical image quality and quantification. In this work, we determined the optimum penalization fa...

Oleneva, V.A.; Taits, N.S.; Kuz'minova, T.A., 1967: Effect of diet reduction on the condition of the cardio-yascular system in obese patients. On the basis of clinical, biochemical, roentgenological and electrocardiographic investigations the symptomatology and factors responsible for the lesion of the heart and vessels in obese patients are analyzed. Particular attention is given to a s...

Seck, D.; Balde, M.; Bah, A., 2015: Dynamics of populations, epidemiology and renewable resources. Acta Biotheoretica 62(3): 241-242

Loy, C.T.; Irwig, L.M.; Katelaris, P.H.; Talley, N.J., 1996: Do commercial serological kits for Helicobacter pylori infection differ in accuracy? A meta-analysis. Objectives: To compare the accuracy of common commercial serological kits for Helicobacter pylori and to ascertain factors affecting accuracy. Methods: A comprehensive MEDLINE and manual search strategy was used to identify all articles comparing...

Papp, L., 1984: Catalogue of Palaearctic Diptera. Volume 9. Lauxaniidae (Sapromyzidae). Unknown

Javadpour, N., 1985: Pharmacology and clinical applications of cis-platinum. Cis-platinum is one of the most efficacious platinum group metals. This agent is widely used in combination with cancer chemotherapy including urologic, gynecologic, esophageal, and head and neck cancers. The initial experience indicated dose-limi...

Garbulinski, T.; Popadiuk, L.; Bula, B., 1957: Effect of massage and muscle contractions on blood circulation. Polski Tygodnik Lekarski 12(11): 381-383

Adcock, L.H., 1966: Trends in solvent analysis. Annals of Occupational Hygiene 9(4): 223-229