+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Regional differences in signalling transduction pathways among smooth muscle cells from rabbit colon

, : Regional differences in signalling transduction pathways among smooth muscle cells from rabbit colon. Cellular Signalling 12(9-10): 683-689, October

Smooth muscle cells (SMC) from the circular muscle layer of rabbit colon, taken from the proximal and distal regions that are known to have different physiological and motor activities, were used to highlight distinct regional intrinsic myogenic properties and to investigate the correlations between receptor and signalling transduction pathways. Contractile agonists were shown to be more potent on proximal than on distal SMC in inducing contraction and intracellular Ca2+ increase. Concentration-response curves of agonists-induced Ca2+ increase were constantly shifted to the right, though remaining parallel, with respect to contraction curves, independently of the region analysed. Using agents activating different steps of cAMP-or cGMP-mediated intracellular cascades, main regional differences were revealed as far as relaxation was concerned. Relaxation of proximal SMC was found to be essentially cGMP mediated, while that of distal SMC was cAMP mediated. In conclusion, the motor patterns of the two regions appear to be influenced by distinct regional biochemical characteristics that are intrinsic to colonic SMC.


PMID: 11080621

DOI: 10.1016/s0898-6568(00)00114-5

Other references

Osvath Iolanda; Samiei Massoud; Carvalho F.P.; Villeneuve J.P., 1998: Sustaining development in the Black Sea region; a sea of changing fortunes. International Atomic Energy Agency Bulletin: , Pages 31-36. 1998.

Broady, P.A., 1977: A new genus and 2 new species of terrestrial chlorophycean algae from signy island south orkney islands antarctica. A new genus and two new species are described and compared with related algae. All were isolated from terrestrial habitats on Signy Island, South Orkney Islands, Antarctica. They are SIGNIOSPHAERA multinucleata gen. et sp. nov. (Tetrasporates, Chl...

van Riel, C.A.H.P.; Meijer-van den Bergh, E.E.M.; Kemps, H.L.M.; Feuth, T.; Schreuder, H.W.B.; Hoogerbrugge, P.M.; D.G.oot, I.J.M.; Mavinkurve-Groothuis, A.M.C., 2015: Self-perception and quality of life in adolescents during treatment for a primary malignant bone tumour. Adolescents experience physical and psychosocial changes as part of their normal development. It can be hypothesized that they have lower scores on Quality of Life (QoL) and self-perception when additional changes occur due to cancer treatment. Th...

Riaz, T.; Riaz, H.; Hasan, M., 2010: Frequency of hypothyroidism in patients with beta-thalassemia. Jpma. Journal of the Pakistan Medical Association 60(2): 159; Author Reply 160-159; Author Reply 160

Girotto, J.A.; Gamble, W.B.; Robertson, B.; Redett, R.; Muehlberger, T.; Mayer, M.; Zinreich, J.; Iliff, N.; Miller, N.; Manson, P.N., 1998: Blindness after reduction of facial fractures. Blindness in patients suffering maxillofacial trauma is usually caused by optic nerve or optic canal injuries. It is, however, an uncommon complication of facial trauma, with a reported incidence of only 2 to 5 percent. Blindness may also follow s...

Deblasi, S., 1964: The use of Dichloroisoproterenol, a "Beta" Adrenolytic Drug, in 2 cases of Pheochromocytoma. Minerva Anestesiologica 30: 157-181

Netter, T.W., 1985: Pollution threatening Swiss and German forests. The problem of forest decline is reviewed in relation to environmental pollution.

de Castro, H.F.; de Lima, R.; Roberto, I.C., 2001: Rice straw as a support for immobilization of microbial lipase. Candida rugosa lipase was covalently immobilized on rice straw activated with glutaraldehyde using poly(ethylene glycol) (PEG) as the stabilizing agent. The effects of PEG molecular weight and enzyme loading were studied according to a full 2(2) f...

Lipsztein, J.L.; Bertelli, L.; Melo, D.R.; Azeredo, A.M.; Julião, L.; Santos, M.S., 1991: Application of in-vitro bioassay for 137Cs during the emergency phase of the Goiânia accident. In the Goiânia accident, many individuals suffered external and internal contamination. The screening of internal contamination was done through 137Cs urinary excretion. During the first month after the accident, only in-vitro bioassay procedures...

Dannecker, G.; Treuner, J.; Buck, J.; Dilger, M.; Niethammer, D., 1985: The combined effect of interferon-beta and cytostatic drugs on human tumor cell lines in vitro. Three human tumor cell lines (one osteosarcoma and two neuroblastoma lines) were assessed for combined interferon-beta (IFN-beta)/chemotherapeutic drug antigrowth effect under in vitro conditions. Two different methods to measure this effect were...