+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Regulation of cholinephosphotransferase by thyroid hormone

, : Regulation of cholinephosphotransferase by thyroid hormone. Biochemical and Biophysical Research Communications 282(4): 861-864

We have demonstrated earlier that thyroid hormone (T3) regulates the activity of cholinephosphotransferase (CPT) in guinea pig lung. This effect of T3 is not organ specific because we found T3 also regulates CPT activity in the guinea pig liver. Northern blot analysis using two oligonucleotide probes, one synthesized on the basis of the yeast CPT gene sequence and another on the basis of partial cDNA clone from guinea pig CPT clone, revealed that T3 stimulates the expression of new CPT mRNA. Studies with transcriptional and translational inhibitors indicated that T3 enhanced the translation of the CPT mRNA as well as translocation of preformed CPT enzyme protein from cytosol to mitochondria. Furthermore, it strengthens our previous finding that yeast CPT and guinea pig CPT have high homology in their sequence as both the oligonucleotide probes gave the similar type of Northern blot in the present study.


PMID: 11352629

DOI: 10.1006/bbrc.2001.4662

Other references

Huang, E-Wen.; Hung, R-Suan.; Chiou, S-Fen.; Liu, F-Ying.; Liou, D-Ming., 2011: Design and development of a tele-healthcare information system based on web services and HL7 standards. Information and communication technologies progress rapidly and many novel applications have been developed in many domains of human life. In recent years, the demand for healthcare services has been growing because of the increase in the elderly...

Moerman, D.G.; Benian, G.M.; Barstead, R.J.; Schriefer, L.A.; Waterston, R.H., 1988: Identification and intracellular localization of the unc-22 gene product of Caenorhabditis elegans. The unc-22 gene is one of a set of genes identified using classical genetics that affect muscle structure and function in the free-living nematode Caenorhabditis elegans. Since cloning the unc-22 gene by transposon tagging, we have used convention...

Mullins, O.C.; Schroeder, R.J.; Rabbito, P., 1994: Effect of high pressure on the optical detection of gas by index-of-refraction methods. An optical method for the detection of gas in high-pressure flow streams has been developed. One can detect gas by measuring the variation in intensity of reflected, p-polarized light at a sapphire-flow stream interface over a range of angles incl...

Yeboah, F.K.; Alli, I.; Yaylayan, V.A., 1999: Reactivities of D-glucose and D-fructose during glycation of bovine serum albumin. Glycation of bovine serum albumin by D-glucose and D-fructose under dry-heating conditions was studied. The reactivities of D-glucose and D-fructose, with respect to their ability to utilize primary amino groups of proteins, to cross-link proteins...

Grady W.C.; Eble C.F.; Blake B.M.; Fedorko N.; Repine T.E., 1992: Relationships of coal beds and strata of the Allegheny Formation and Pottsville Group of northern and central West Virginia to the proposed Pennsylvanian System stratotype of southern West Virginia. Abstracts with Programs - Geological Society of America 24(3): 25

Eliakim M., 1970: Proceedings of the 4th asian pacific congress of cardiology section on heart beat and methods of registration jerusalem tel aviv israel september 1 7 1968. Eliakim, Marcel (Edited By) Proceedings Of The 4th Asian-Pacific Congress Of Cardiology 515p Illus Academic Press Inc : New York, N Y , U S A ; London, England 92-121

Distler, A., 1975: The renin-angiotensin-aldosterone system in essential hypertension. Medizinische Klinik 70(16): 691-697

Montero C.O., 1975: Techniques of geochemical prospecting for uranium in Colombia. Geologia Colombiana 9): 65-83

Almeer, S.H.M.A.; Zogby, I.A.; Hassan, S.S.M., 2014: Novel miniaturized sensors for potentiometric batch and flow-injection analysis (FIA) of perchlorate in fireworks and propellants. Three planar miniaturized perchlorate membrane sensors (3×5 mm(2)) are prepared using a flexible Kaptan substrate coated with nitron-perchlorate (NT-ClO4) [sensor 1], methylene blue-perchlorate (MB-ClO4) [sensor II] and indium-porphyrin (In-Por)...

Oscar T.P.; Spears J.W., 1987: Performance and ruminal fermentation changes associated with dietary nickel supplementation to growing beef steers. Journal of Animal Science 65(SUPPL 1): 27-28