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Relationship between circulating serum soluble interleukin-6 receptor and the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in multiple myeloma


, : Relationship between circulating serum soluble interleukin-6 receptor and the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in multiple myeloma. Annals of Hematology 82(1): 19-23

Angiogenesis plays an important role in multiple myeloma (MM) progression. Various mitogens such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (FGF-2) have been implicated in the angiogenic process of various malignancies. Interleukin-6 (IL-6) is a growth factor of myeloma cells and its signaling is mediated via a cell surface receptor complex (IL-6r). IL-6 and tumor necrosis factor-alpha (TNF-alpha) are involved in the secretion of VEGF by IL-6r expressing myeloma cells. In this study, serum FGF-2, VEGF, IL-6r, and TNF-alpha were measured in 46 untreated MM patients and were studied in relation to disease stage (by Salmon-Durie criteria) and severity [assessed by serum beta(2)-microglobulin (beta(2)M), C-reactive protein (CRP), alpha(1)-antitrypsin (alpha(1)AT), and lactic dehydrogenase (LDH) levels]. The results showed that FGF-2, VEGF, IL-6r, and TNF-alpha were significantly elevated in MM patients in comparison to controls ( p<0.008) and were significantly higher in stage III disease in comparison to stages I and II ( p<0.03). The mean concentrations of IL-6r were 877+/-374, 1220+/-308, 1431+/-878, and 453+/-180 pg/ml for stages I, II, and III and controls, respectively. Levels of beta(2)M, alpha(1)AT, CRP, and LDH were all significantly higher in MM patients than controls and increased with advancing stage of disease. There were positive correlations of both VEGF and FGF-2 with IL-6r, TNF-alpha, beta(2)M, alpha(1)AT, CRP, and LDH. We conclude that IL-6r and TNF-alpha increase in parallel to VEGF and FGF-2 with increasing stage of MM disease. These molecules correlate with biochemical markers of disease activity and may play a role in the progression of multiple myeloma.

US$19.90

PMID: 12574959

DOI: 10.1007/s00277-002-0558-0


Other references

Bender, ES., 1981: Recovery of macroinvertebrate stream communities from chronic DDT contamination. Dissertation Abstracts International B Sciences and Engineering, 423: 891

Morris, C.L.; Sullivan, J.S.; McClure, H.M.; Strobert, E.; Richardson, B.B.; Galland, G.G.; Goldman, I.F.; Collins, W.E., 1996: The Nigerian I/CDC strain of Plasmodium ovale in chimpanzees. The chimpanzee is the only animal host currently available that can support the development of the human malaria parasite Plasmodium ovale. Thirty-one infections with the Nigerian I/CDC strain were induced in splenectomized chimpanzees. Maximum pa...

Sochman J.; Kolc J.; Vrana M.; Fabian J., 1990: N acetylcysteine effect of myocardial infarction in dogs. Ceskoslovenska Fysiologie 39(6): 513-516

Brieger, P.; Kling Lourenço, P.; Steinert, T.; Längle, G.; Lemke, U.; Herpertz, S.C.; Croissant, D.; Becker, T.; Kilian, R., 2014: Involuntary psychiatric hospital admissions: a comparison between five hospitals in three German federal states. There is considerable variance in involuntary psychiatric hospital admission rates both in Europe and Germany. In a prospective comparison between five hospitals in three German federal states we assessed and analyzed involuntary psychiatric hospi...

De la Torre, C.; Losada, A.; Cruces, M.J., 1999: Necrobiosis lipoidica: a case with prominent cholesterol clefting and transepithelial elimination. Transepithelial elimination of degenerated collagen through the hair follicle in necrobiosis lipoidica is rare, clinically manifesting as comedo-like plugs. Also unusual in necrobiosis lipoidica is the finding of cholesterol cleft formation. We re...

Blowes, D., 2002: Environmental chemistry. Tracking hexavalent Cr in groundwater. Science 295(5562): 2024-2025

Brown, C.B.; Hansell, J.R.F.; Hill, I.D.; Stark, J.; Smith, G.W., 1965: Land capability survey of Trinidad and Tobago. No. 1. Tobago. A short introduction describing the scope of this study is followed by 3 chapters on soil survey, aspects of land use and land capability, and a note on dry-season irrigation needs. The lines which should be followed in future investigations and r...

Arkhangelskaya, E.P., 1956: The dynamics of changes in the blind spot of one eye in traumatic conditions of the other eye. In 100 patients with various traumatic conditions of the eye, there was noted an enlargement of the blind spot of the healthy eye in 89% of the cases. The duration and the extent of the enlargement of the blind spot was in direct relationship to t...

Hallberg R.O., 1978: The microbiological carbon nitrogen sulfur cycles in sediments and their effect on the ecology of the sediment water interface. Oikos (suppl 15): 51-62

Hoi, Y.; Meng, H.; Woodward, S.H.; Bendok, B.R.; Hanel, R.A.; Guterman, L.R.; Hopkins, L.Nelson., 2004: Effects of arterial geometry on aneurysm growth: three-dimensional computational fluid dynamics study. Object. Few researchers have quantified the role of arterial geometry in the pathogenesis of saccular cerebral aneurysms. The authors investigated the effects of parent artery geometry on aneurysm hemodynamics and assessed the implications relativ...