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Reperfusion injury: Experimental evidence and clinical implications

, : Reperfusion injury: Experimental evidence and clinical implications. American Heart Journal 138(2 PART 2): S69-S75, Aug

Postischemic reperfusion may profoundly alter cardiac function. Principal mediators of this phenomenon are oxygen radicals and neutrophils. Upon reflow, oxygen radicals are generated in large amounts, overwhelming cellular defenses and inducing oxidative tissue damage; biochemical markers of oxygen radical formation and attack can be found in postischemic myocardium. Reintroduction of neutrophils in postischemic tissues is accompanied by their activation, with release of lytic enzymes that directly induce tissue damage and proinflammatory mediators that amplify the local inflammatory reaction. Neutrophils may also plug capillaries, mechanically blocking flow. Oxidants can also modulate various events, ultimately leading to tissue injury, such as nitric oxide formation, platelet-activating factor metabolism, tissue factor synthesis, and exposure of adhesion molecules. In the clinical setting, important consequences of postischemic reperfusion are reversible contractile dysfunction ("stunning"), which is mostly caused by oxygen radical attack, and impairment to flow at the microvascular level ("no-reflow") secondary to neutrophil plugging and vasoconstriction.


PMID: 10426862

DOI: 10.1016/s0002-8703(99)70323-6

Other references

Seth, M.L.; Raychaudhuri, S.P.; Singh, D.V., 1972: A mosaic disease of pearl-millet (Pennisetum typhoides (Burm. f.) Stapf & C.E. Hubb.) in India. The disease was transmitted by sap and by Rhopalosiphum maidis. The thermal inactivation point of the virus was 50-52 deg C, dilution end point 1:500 - 1:1000, longevity at 32 deg 8-16 h and at 7 deg c. 1 week. A list of susceptible Gramineae is g...

Suzuki, T.; Takemoto, T.; Kashiwazaki, H.; Togo, M.; Toyokawa, H., 1976: Man, fish, and mercury on small islands in Japan. This paper examines the differentiating patterns of subsistence activities, fish-eating habit, mercure level in human biological specimens, and the interrelation among these variables on several small Japanese islands. The catch and supply of fish...

Kawamata, J.; Ikeda, A.; Fujita, Y.; Usui, K.; Shimohama, S.; Takahashi, R., 2010: Mutations in LGI1 gene in Japanese families with autosomal dominant lateral temporal lobe epilepsy: the first report from Asian families. Autosomal dominant lateral temporal lobe epilepsy (ADLTE) caused by LGI1 (leucine-rich gene, glioma-inactivated-1) mutations is a rare familial epileptic syndrome characterized by the auditory ictal manifestation and rare nocturnal generalized sei...

Tarrier, Michel., 1995: New record of Relictocarabus meurguesianus Ledoux 1989, in the High Atlas Col Carabidae Nouvelle presence de Relictocarabus meurguesianus Ledoux 1989, dans le Haut Atlas Col Carabidae. Entomologiste (Paris). Decembre; 516: 293

Parisod, C.; Christin, P-Antoine., 2008: Genome-wide association to fine-scale ecological heterogeneity within a continuous population of Biscutella laevigata (Brassicaceae). Gene flow, drift and selection can be detected through different signatures across the genome and the landscape. Genetic discontinuities along with their correlation to environmental features can be used to tease out isolation-by-distance and isol...

Barsky, E., 2015: A supplement to the nursing degree. Soins. Pediatrie, Puericulture: 5-5

Lin, C.Joe.; Woldegiorgis, B.Haile., 2017: Kinematic analysis of direct pointing in projection-based stereoscopic environments. This work investigated the effects of visual information, parallax, and target positions on movement performances in projection-based stereoscopic displays (PSDs). Fifteen (26.5 ± 3.83 years) self-declared right-handed individuals, with nor...

Barbieri, G.; Barbieri, M., 1984: Dinamica da repoducao de Gymnotus carapo na represa do lobo, estado de Sao Paulo. Influencia de factores abioticos (Pisces, Gymnotidae). Tropical Ecology 24(2): 244-259

Sawai, T.; Negishi, M.; Nishigaki, N.; Ohno, T.; Ichikawa, A., 1993: Enhancement by protein kinase C of prostacyclin receptor-mediated activation of adenylate cyclase through a calmodulin/myristoylated alanine-rich C kinase substrate (MARCKS) system in IC2 mast cells. The addition of 12-O-tetradecanoylphorbol-13-acetate (TPA) markedly enhanced cAMP formation induced by carbacyclin, a stable prostacyclin analogue, in cultured mast cells (IC2 cells), but did not enhance basal or NaF plus AlCl-3-induced cAMP forma...

Rajan, S., 1967: Food of some hill stream fishes of South India. Journal of the Zoological Society of India. 1965 ; 17: 8-17