geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Residential and recreational acquisition of possible estuary-associated syndrome: a new approach to successful diagnosis and treatment


, : Residential and recreational acquisition of possible estuary-associated syndrome: a new approach to successful diagnosis and treatment. Environmental Health Perspectives 109 Suppl 5: 791-796

Evidence suggests that the estuarine dinoflagellates, Pfiesteria piscicida Steidinger & Burkholder and P. shumwayae Glasgow & Burkholder, members of the toxic Pfiesteria complex (TPC), may release one or more toxins that kill fish and adversely affect human health. In the current study we investigated the potential for undiagnosed cases of possible estuary-associated syndrome (PEAS), as termed by the Centers for Disease Control and Prevention (CDC), in a population that had residential and/or recreational exposure to TPC-affected estuaries, but that did not have direct contact with fish kills or lesioned fish. Age-adjusted visual contrast sensitivity (VCS) was significantly lower and the presence of PEAS-associated symptoms was much higher in the estuary cohort (n = 77) than in combined-control cohorts (n = 87), one without exposure to bodies of water (n = 53) and one with exposure to marine waters (n = 34). In the estuary cohort, 37 individuals met the CDC case definition for PEAS and had significantly lower VCS than non-PEAS cases. The VCS improved and symptoms abated after 2 weeks of treatment with cholestyramine. Cholestyramine, the original drug approved for treatment of hypercholesterolemia, has previously been reported to enhance the elimination rates of a variety of toxins, presumably by interruption of enterohepatic recirculation through toxin entrapment in its polymeric structure and/or anion-exchange process. Control studies showed that repeated VCS testing alone did not improve VCS scores and that cholestyramine treatment did not affect VCS in patients with elevated cholesterol levels. These results suggested that a) susceptible individuals may acquire PEAS through residential and/or recreational contact with TPC-affected estuaries in the absence of an active fish kill; b) VCS is a useful indicator in PEAS diagnosis and treatment monitoring; and c) PEAS can be effectively treated with cholestyramine. Because the study did not use population sampling techniques, the results do not indicate PEAS prevalence. Furthermore, definitive diagnosis of PEAS and association with TPC toxin(s) must await identification of, and a serologic test for, the putative TPC toxin(s).

US$29.90

PMID: 11677191


Other references

Bankoul, S.; Neuhuber, W.L., 1990: A cervical primary afferent input to vestibular nuclei as demonstrated by retrograde transport of wheat germ agglutinin-horseradish peroxidase in the rat. Wheat germ agglutinin-horseradish peroxidase conjugate (WGA-HRP) was microiontophoretically injected into the vestibular nuclear complex of the rat. Retrogradely labeled neurons were found in ipsilateral spinal ganglia C2-C3 only if the injection...

Alivizatos, G.; Ferakis, N.; Mitropoulos, D.; Skolarikos, A.; Livadas, K.; Kastriotis, I., 2005: Feedback microwave thermotherapy with the ProstaLund Compact Device for obstructive benign prostatic hyperplasia: 12-month response rates and complications. Purpose: To evaluate the effectiveness of the ProstaLund (R) Compact Device in the treatment of benign prostatic hyperplasia (BPH).Patients and Methods: A series of 38 consecutive patients with a mean age of 72.6 +/- 8.2 years, 19 with an indwelli...

Czarnecki, S.W.; Hopeman, A.R.; Child, P.L., 1964: Tetralogy Of Fallot With Aortic Origin Of The Left Pulmonary Artery: Radiographic And Angiocardiographic Considerations. Report Of A Case. Diseases of the Chest 46: 97-101

Garasky, S.a.; Stewart, S.D.; Gundersen, C.; Lohman, B.J.; Eisenmann, J.C., 2010: Family stressors and child obesity. Child obesity is a public health priority with numerous and complex causes. This study focuses on factors within the family, namely stressful experiences, which may be associated with child obesity. We examine data from the Child Development Suppl...

Kim, J.Tae.; Kim, S.Wha., 2015: Another option of perforator flap in the lateral thoracic area: lateral thoracic perforator flap. The lateral thoracic donor site provides two types of perforator flap; the latissimus dorsi perforator flap based on the musculocutaneous perforator, and the thoracodorsal perforator flap based on the septocutaneous perforators from the thoracodor...

Awada, M.; Soulage, C.O.; Meynier, A.; Debard, C.; Plaisancié, P.; Benoit, Bérengère.; Picard, Gégory.; Loizon, E.; Chauvin, M-Agnès.; Estienne, M.; Peretti, Nël.; Guichardant, M.; Lagarde, M.; Genot, C.; Michalski, M-Caroline., 2013: Dietary oxidized n-3 PUFA induce oxidative stress and inflammation: role of intestinal absorption of 4-HHE and reactivity in intestinal cells. Dietary intake of long-chain n-3 PUFA is now widely advised for public health and in medical practice. However, PUFA are highly prone to oxidation, producing potentially deleterious 4-hydroxy-2-alkenals. Even so, the impact of consuming oxidized n...

Leclerc, J.; Tournel, G.; Courcot-Ngoubo Ngangue, E.; Pottier, N.; Lafitte, J-Jacques.; Jaillard, S.; Mensier, E.; Lhermitte, M.; Broly, F.; Lo-Guidice, J-Marc., 2010: Profiling gene expression of whole cytochrome P450 superfamily in human bronchial and peripheral lung tissues: Differential expression in non-small cell lung cancers. Susceptibility to lung diseases, such as lung cancer and chronic obstructive pulmonary disease, is largely influenced by the metabolic capacity of lung tissues. This capacity is partly determined by the expression profile of the cytochromes P450 (...

Korniushenko, N.P., 1974: Nina Petrovna Korniushenko (on her 70th birthday). Mikrobiolohichnyi Zhurnal 36(6): 806-806

Watrous, R.L., 1991: Current status of Peterson-Barney vowel formant data. A question concerning the status of the Peterson-Barney vowel formant data is raised. Two machine-readable copies of the data were located, compared, and found to contain minor discrepancies. These discrepancies were resolved by comparison with a...

Haldemann, C.; Fuhrer, J., 2005: Interactive effects of CO2 and O3 on the growth of Trisetum falvescens and Trifolium pratense grown in monoculture or a bi-species mixture. Golden oat grass (Trisetum flavescens L.) and red clover (Trifolium pratense L.) were grown as monocultures or bi-species mixtures under controlled conditions and exposed to ambient (350 ppm) or elevated (580 ppm) CO2, with or without addition of...