geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Resistance artery smooth muscle function in pregnancy and preeclampsia


, : Resistance artery smooth muscle function in pregnancy and preeclampsia. American Journal of Obstetrics & Gynecology 186(1): 148-154, January

OBJECTIVE: The purpose of this study was to investigate whether the altered vascular resistance in pregnancy and preeclampsia results from alterations in intrinsic vascular smooth muscle properties or from external influences on vascular smooth muscle function. STUDY DESIGN: We studied subcutaneous resistance arteries from women with preeclampsia, from normal pregnant women, and from nonpregnant women, that were obtained during cesarean delivery or gynecologic surgical procedures, in a pressure myograph. Arteries were denervated, and smooth muscle cells were loaded with calcium indicator fura-2. Contractile properties were tested in physiologic saline solution and during potassium- and norepinephrine-induced constriction at various pressures. In addition, endothelial function was assessed. Intracellular calcium and tone were measured continuously. RESULTS: No significant differences in basal tone, constrictor, and myogenic responses were found between groups. Contractile element calcium sensitivity was significantly increased in women with preeclampsia. Norepinephrine caused an increase in calcium sensitivity in all groups. CONCLUSION: Vascular smooth muscle calcium sensitivity is increased in preeclampsia.

US$19.90

PMID: 11810101

DOI: 10.1067/mob.2002.119184


Other references

Hinman, F.; Cohlan, W.R., 1960: Gartner's duct carcinoma in a urethral diverticulum. Journal of Urology 83: 414-415

Alagkiozidis, I.; Facciabene, A.; Tsiatas, M.; Carpenito, C.; Benencia, F.; Adams, S.; Jonak, Z.; June, C.H.; Powell, D.J.; Coukos, G., 2011: Time-dependent cytotoxic drugs selectively cooperate with IL-18 for cancer chemo-immunotherapy. Time-dependent chemotherapeutic agents can selectively target tumor cells in susceptible phases of the cell cycle however a fraction of tumor cells in non-vulnerable cell cycle phases remain drug-resistant. Immunotherapy represents a promising app...

Nouwen, A.; Freeston, M., H.; Cournoyer, I.; Deschesnes, F.; Boulet, L.-Phillippe, 1994: Perceived symptoms and discomfort during induced bronchospasm: The role of temporal adaptation and anxiety. Using a mixed within-between design, this study was designed to evaluate the sensorial and cognitive/evaluative aspects of bronchoconstriction induced by progressive methacholine inhalation. 25 asthmatic patients and 15 normal controls were given...

Heasley, V.L.; Buczala, D.M.; Chappell, A.E.; Hill, D.J.; Whisenand, J.M.; Shellhamer, D.F., 2002: Addition of bromine chloride and iodine monochloride to carbonyl-conjugated, acetylenic ketones: synthesis and mechanisms. The reactions of 3-butyn-2-one (1), 3-hexyn-2-one (2), and 4-phenyl-3-butyn-2-one (3) with bromine chloride (BrCl) and iodine monochloride (ICl) in CH(2)Cl(2), CH(2)Cl(2)/pyridine, and MeOH are described. The data show that the major products in C...

Rosenbaum, B.; Kinney, M.J.; Scudder, F.C.; DiScala, V.A.; Stein, R.M., 1972: Effects of potassium depletion on renal tubular sodium and water reabsorption in the dog. Renal clearance studies were made on dogs to estimate the effects of K depletion (KD) on renal tubular Na and water transport. After KD, glomerular filtration rate (GFR) fell in all dogs. Under hydropenic conditions plus hypertonic mannitol loadin...

Wang HuiLi; Han SuFen; Zhao BoGuang, 2004: Distribution and pathogenicity of bacteria carried by pine wood nematode in epidemic regions and hosts. Twenty-four bacteria strains were isolated from Pinus thunbergii and Pinus massoniana trees infected by pine wood nematode (Bursaphelenchus xylophilus). Specimen were collected in Jiangsu, Shanghai, Guangdong, Anhui, Hubei and Zhejiang Province, C...

Kaschani, F.; Gu, C.; Niessen, S.; Hoover, H.; Cravatt, B.F.; van der Hoorn, R.A.L., 2009: Diversity of serine hydrolase activities of unchallenged and botrytis-infected Arabidopsis thaliana. Activity-based protein profiling is a powerful method to display enzyme activities in proteomes and provides crucial information on enzyme activity rather than protein or transcript abundance. We applied activity-based protein profiling using fluo...

Anonymous, 2007: It takes all CM functions to provide necessary care. Hospital Case Management 15(4): 63-64

Basch, C.M.; Rosenbaum, E.H., 1969: Multiple myeloma. Clinical correlation of immunoglobulin changes with therapy. A report of 23 cases. Twenty-three patients with multiple myeloma were studied. They were grouped according to their clinical response and changes in myeloma globulin in the serum or urine while under chemotherapy. Sixteen responded favorably with clinical improvement...

Vagnoni, L.M.; Gronostaj, M.; Kerrigan, J.E., 2001: 6-Acylamino-2-1[(ethylsulfonyl)oxy]-1H-isoindole-1,3-diones mechanism-based inhibitors of human leukocyte elastase and cathepsin G: effect of chirality in the 6-acylamino substituent on inhibitory potency and selectivity. Inhibition of human leukocyte elastase(HLE) by a series of 6-acylamino-2-[(ethylsulfonyl)oxy)]-1H-isoindole-1,3-diones was determined and compared to their inhibition of ChT, PPE, and Cat G. The best inhibitor of the series was 6-((1'S)-camph...