+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Schizophrenia: Glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo

, : Schizophrenia: Glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo. European Journal of Neuroscience 12(10): 3721-3728, October

Schizophrenia is a major psychiatric disease, which affects the centre of the personality, with severe problems of perception, cognition as well as affective and social behaviour. In cerebrospinal fluid of drug-free schizophrenic patients, a significant decrease in the level of total glutathione (GSH) by 27% (P<0.05) was observed as compared to controls, in keeping with the reported reduced level of its metabolite gamma-glutamylglutamine. With a new non-invasive proton magnetic resonance spectroscopy methodology, GSH level in medial prefrontal cortex of schizophrenic patients was found to be 52% (P = 0.0012) lower than in controls. GSH plays a fundamental role in protecting cells from damage by reactive oxygen species generated among others by the metabolism of dopamine. A deficit in GSH would lead to degenerative processes in the surrounding of dopaminergic terminals resulting in loss of connectivity. GSH also potentiates the N-methyl-D-aspartate (NMDA) receptor response to glutamate, an effect presumably reduced by a GSH deficit, leading to a situation similar to the application of phencyclidine (PCP). Thus, a GSH hypothesis might integrate many established biological aspects of schizophrenia.


PMID: 11029642

DOI: 10.1046/j.1460-9568.2000.00229.x

Other references

Shanidze, M.G., 1979: Egg laying of the female Varroa mite. Four types of egg were identified; the type which predominated from February to May was oval, white, 0.47 X 0.58 mu m, with a larva forming within the membrane. From June to October the main type was yellowish-white, round, soft, 0.41 X 0.48 mu m,...

Mahoney, J.M., 1997: Factor structure of Ellis' irrational beliefs in a nonclinical college population. In a study of irrational beliefs among nonclinical populations, 54 male and 75 female college students completed the Irrational Beliefs Survey. Analysis suggests that the survey measures a coherent construct and that a simple summary score is adeq...

Brion, J.P.; Flament-Durand, J., 1995: Distribution and expression of the alpha-tubulin mRNA in the hippocampus and the temporal cortex in Alzheimer's disease. The distribution of the messenger RNA for alpha-tubulin has been investigated by in situ hybridization in the human hippocampus and temporal cortex in normal subjects and in Alzheimer's disease. The alpha-tubulin mRNA was strongly expressed i...

Lane, J.A., 1993: Returning Gospel values to nursing education. Catholic educators and institutions must make explicit the values on which their practices are based. Although Catholic nursing education in the United States has traditionally instilled Gospel values in students, pressures from a secular culture are making it increasingly difficult to sustain this heritage. As the twenty-first century approaches,...

Feder, B.M.; Hurvitz, A.I., 1990: Feline immunodeficiency virus infection in 100 cats and association with lymphoma. Of 2533 cats from New York City examined in May 1988 to May 1989, 113 (4.5%) were found to be infected with feline immunodeficiency virus. Of 100 infected cats 85 were ill and 15 did not show symptoms. Lymphoma was diagnosed in 25% of infected cat...

Weyde, R., 1947: The treatment of lymph node metastases from intra oral carcinomas with special regard to the indications for total neck dissection. Acta Radiologica 28(4): 367-385

Ono, T.; Goodman, D.B.; Rasmussen, H.; Omura, S., 1974: A new type of sodium transport inhibitor in the toad bladder. Journal of Membrane Biology 18(3-4): 295-304

Appleby, J., 1996: "My child has asthma": some answers to parents' questions. The incidence of asthma appears to have doubled since the 1970s. 15% of children in the UK are now estimated to have the condition. Children's asthma needs to be taken seriously by parents, health professionals and teachers. Its severity vari...

Noordeloos, M.; Gulden, G., 2004: The genus Entoloma (Basidiomycetes, Agaricales) on Svalbard. An account is given of 13 species of Entoloma recorded from the arctic archipelago of Svalbard, with three taxa - E. milleri, E. atrosericeum var. fusipes, and E. svalbardense - being new to science. Seven species are new to Svalbard.

Drenth, B.J.; Grauch, V.J.S., 2011: Digital data from the northeast Tusas Mountains aeromagnetic survey, Rio Arriba and Taos Counties, north-central New Mexico. This report contains digital data, image files, and text files describing data formats and survey procedures for a high-resolution aeromagnetic survey in the northeast Tusas Mountains region of north-central New Mexico. The survey covers a large p...