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Serum mullerian-inhibiting substance levels during normal menstrual cycles


, : Serum mullerian-inhibiting substance levels during normal menstrual cycles. Fertility & Sterility 73(4): 859-861, April

Objective: To measure serum levels of mullerian-inhibiting substance (MIS) during the normal menstrual cycle. Design: Serum was collected from women during ovulation and the mid-luteal and early follicular phases of the menstrual cycles. It was stored frozen at -80degreeC until assayed. Setting: University of Louisville Departments of Obstetrics and Gynecology and Surgery. Patient(s): Twenty healthy women 22-35 years of age with normal menstrual cycles. Intervention(s): Blood samples were collected on menstrual cycle day two or three and on the day of LH surge plus one and plus seven or eight. Main Outcome Measure(s): Serum MIS levels were measured by using an enzyme-linked immunosorbent assay. Result(s): Serum MIS levels ranged from a low of 1.4 +- 0.9 ng/mL (mean (+-SD)) in the early follicular phase, peaked mid-cycle at 1.7 +- 1.1 ng/mL, and decreased to 1.4 +- 0.9 ng/mL in the mid-luteal phase of the normal menstrual cycle. Conclusion(s): Fluctuations in serum MIS levels during the menstrual cycle suggest that MIS may have a regulatory role in folliculogenesis.

US$29.90

PMID: 10731554


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