+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Serum sickness induced by bupropion

, : Serum sickness induced by bupropion. Annals of PharmacoTherapy 33(9): 931-933

OBJECTIVE: To describe the first reported case of serum sickness induced by exposure to bupropion. CASE SUMMARY: Bupropion was administered to a 45-year-old white man being treated for depression with psychosis. Within 24 hours after his first dose of bupropion, the patient became delirious and then developed fever, myalgia, arthralgia, and a rash. Bupropion was discontinued after the second dose. With supportive measures, symptoms remitted over two weeks. DISCUSSION: A thorough search for other etiologies of the patient's symptoms was unrevealing, and a clinical diagnosis of serum sickness was made. Given the temporal association between the illness and the introduction of bupropion, this was felt to be the causal agent. No previous reports of serum sickness induced by bupropion were found in the literature. CONCLUSIONS: The previously unreported adverse drug reaction of serum sickness associated with the use of bupropion is demonstrated by this case, based on the temporal relationship and the results of stopping the drug, in light of no other identifiable etiology.


PMID: 10492492

DOI: 10.1345/aph.18418

Other references

Boyd John E., 1981: Image enhancement through film recorder response contouring. Proceedings of SPIE - The International Society for Optical Engineering 278: 157-166

Holt, E.William., 2013: Describing the role of ethnicity in the progression of NAFLD: easier said than done?. Hepatology 56(5): 2005; Author Reply 2005-6

Baum, L.O.; Murray, J.A.; Oldham, H.N., 1961: Evaluation of lung volumes and intrapulmonary gas mixing in diseased and normal children. Diseases of the Chest 39: 28-37

Marcantonio, J.M.; Syam, P.P.; Liu, C.S.C.; Duncan, G., 2003: Epithelial transdifferentiation and cataract in the human lens. Anterior subcapsular cataracts cause a serious loss of vision and are normally associated with ocular trauma, inflammation or clinical skin conditions. They appear to be accompanied by epithelial cell growth and transdifferentiation where unschedu...

Bishop, B.P.; Krasney, J.A.; Rifkin, D.; Megirian, D.; Roberts, A.; Shucard, D., 2001: Ambient temperature differentially affects daily rhythms of body temperature and level of activity in rats. In nocturnal rat, Tb and La are high during darkness (d) and low during light (l). To determine whether Ta affects these Tb and La rhythms we measured the periods, magnitudes, rise times, phase durations and phase-shifts of the Tb and La cycles in...

D.Haas J.H., 1978: Risk factors of coronary heart disease in children a retrospective view of the westland study. Postgraduate Medical Journal 54(629): 187-189

Van Gijseghem, H.; Gauthier, M.C.antal, 1994: Links between sexual abuse in childhood and behavioral disorders in adolescent girls A multivariate approach. Canadian Journal of Behavioural Science 26(3): 339-352

Kudler, G.D., 1975: The non-parallel pin splinting system. New York State Dental Journal 41(1): 12-18

Mou, C.; Ganju, N.; Krishan, A., 1996: Simultaneous quantitation of plasma doxorubicin and prochlorperazine content by HPLC. Proceedings of the American Association for Cancer Research Annual Meeting 37(0): 366

Konorski, J., 1968: A review of the brain research carried out in the Department of Neurophysiology of the Nencki Institute of Experimental Biology. Acta Biologiae Experimentalis 28(4): 257-289