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Short-term changes in lower leg length in children treated for acute lymphoblastic leukaemia


, : Short-term changes in lower leg length in children treated for acute lymphoblastic leukaemia. Journal of Pediatric Endocrinology & Metabolism 12(1): 75-80

The lower leg length velocity (LLLV) of 14 children with a median age of 4.5 yr who were undergoing chemotherapy (CT) for acute lymphoblastic leukaemia (ALL) was studied for a median duration of 56 weeks (range 14-112). Nine children were studied over the first 6 months, six over the first year, four over the full 2-year course and nine children over the 3 months before and after the end of CT. Over the first month of CT, during induction, median LLLV was 0 mm/wk (P5, P95: -1.6, 0.11); during the fourth month of CT, at the end of CNS-directed therapy, there was a significant rise to 0.38 mm/wk (P5, P95: -0.04, 0.81; p = 0.01, WSR). In the children measured following the end of CT, median LLLV rose from 0.46 mm/wk (P5, P95: -0.02, 0.79) in month 23 to 0.84 mm/wk (P5, P95: 0.72, 1.12) (p = 0.03). There was a positive relationship between neutrophil count and LLLV during continuation chemotherapy (r = 0.4, p = 0.0002); median LLLV was 0.2 mm/ wk (P5, P95: -0.15, 0.5) when the neutrophil count was less than 1 x 10(9)/l and 0.65 mm/wk (P5, P95: 0.1, 1.0) (p = 0.01) when the count was above 1 x 10(9)/l. No significant differences in LLLV were observed between children randomised to different UKALLXI regimens. Intensive chemotherapy for ALL adversely affects lower leg growth. Growth was subnormal during the first few weeks of chemotherapy, but was comparable to healthy children during CNS directed and continuation therapy. There was a significant relationship between growth velocity and neutrophil count during continuation chemotherapy. On discontinuation of chemotherapy there was a further acceleration in lower leg length velocity to supranormal levels ("catch-up" growth).

US$19.90

PMID: 10392351

DOI: 10.1515/JPEM.1999.12.1.75


Other references

Weisfeld, G.E.; Czilli, T.; Phillips, K.A.; Gall, J.A.; Lichtman, C.M., 2003: Possible olfaction-based mechanisms in human kin recognition and inbreeding avoidance. Three studies explored kin recognition through olfaction. In Study I, adults (N = 22) were tested for ability to identify the odors of themselves; their mother: their father; a sister; a brother; a familiar, unrelated individual; and a stranger. A...

Matsuda, M.; Wakabayashi, K.; Murayama, H., 1982: Vitamin K-dependent blood coagulation factors in surgical patients. Nihon Ketsueki Gakkai Zasshi 45(4): 840-848

Macnaughton, J., 1998: Medicine and the arts: let's not forget the medicine. British Journal of General Practice 48(427): 952-953

Shchelko, L.G., 1980: Race-specific resistance of barley to loose smut, Ustilago nuda (Jens.) Kell. & Sw., and principles of selecting initial material for breeding. Eight spring barley specimens were inoculated with races 1, 6, 11, 16 and 17 of U. nuda from different regions of the USSR. Cvs. for breeding are recommended for different areas. Jet (with the resistance genes UN3, Un4, Un5 and Un6) and the Americ...

Tanaka, T.I.o, T.N.kaya, K.I.numa, M.R.swan, S., 2000: Oligostilbenoids in stem bark of Vatica rassak. Three resveratrol oligomers, vaticanols. A, B and C, as well as three known stilbenoids, resveratrol, piceid and epsilon-viniferin were isolated from the stem bark of Vatica rassak (Dipterocarpaceae). Their structures were determined by the analys...

Mango Frank D., 1989: The thermal stability of sedimentary hydrocarbons at very high subsurface temperatures. Abstracts with Programs - Geological Society of America 21(6): A48

Han, Y-Hyun.; Hong, S-Jong.; Cheong, H-Kap.; Chung, Y.Je., 2013: Crystal structures of 26kDa Clonorchis sinensis glutathione S-transferase reveal zinc binding and putative metal binding. The crystal structures of CsGST in two different space groups revealed that Asp26 and His79 coordinate a zinc ion. In one space group, His46 of an adjacent molecule participates in the coordination within 2.0Å. In the other space group, Asp26, Hi...

Cha, F.Ng.S.T.; Gowen, J.W., 1957: The developmental effect of a sex-limited gene in Drosophila melanogaster. Hermaphroditic phenotypes in Drosophila melanogaster resulting from the developmental action of a mutant gene (Hr) are described. This gene is an example of a single gene which causes major changes in sex types. It is dominant to the wild type fem...

Stickel, F.; Droz, S.; Patsenker, E.; Bögli-Stuber, K.; Aebi, B.; Leib, S.L., 2008: Severe hepatotoxicity following ingestion of Herbalife nutritional supplements contaminated with Bacillus subtilis. Nutritional supplements are widely used. Recently, liver injury after consumption of Herbalife preparations was reported but the underlying pathogenesis remained cryptic. Two patients presented with cholestatic hepatitis and pruritus, and cirrhosi...

Bergsten, Christer, 2004: Lameness and claw lesions as influenced by stall environment and cow comfort. Medecin Veterinaire du Quebec 34(1-2): 29-31