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Synergistic effect of thrombomodulin promoter -33G/A polymorphism and smoking on the onset of acute myocardial infarction


, : Synergistic effect of thrombomodulin promoter -33G/A polymorphism and smoking on the onset of acute myocardial infarction. Thrombosis and Haemostasis 87(1): 86-91

Thrombomodulin is an endothelial cell surface receptor for thrombin. It plays an important role in the regulation of blood coagulation by decreasing thrombin activity and activating protein C. This study examined the possible association between the thrombomodulin -33G/A polymorphism and acute myocardial infarction. We recruited 278 patients (mean age 57.5 years, 241 men) with documented myocardial infarction and 450 age- and sex-matched control subjects. Polymerase chain reaction and single-strand conformation polymorphism was used to define the thrombomodulin -33G/A polymorphism. The frequency of the thrombomodulin GA+AA genotype among patients with myocardial infarction was higher than that in control subjects (22.7% vs. 16.2%, odds ratio [OR] 1.5, 95% confidence interval [CI] 1.0 to 2.2). The -33G/A polymorphism (GA+AA genotype) was significantly associated with myocardial infarction (OR 1.6, 95% CI 1.1 to 2.5) as was hypertension, diabetes mellitus and smoking. Among young myocardial infarction patients (age < or =45 years, n = 72), the frequency of -33G/A polymorphism was more significantly higher than that in control subjects (29.2% vs. 16.2%, OR 2.1, 95% CI 1.2 to 3.8). The -33G/A polymorphism (OR 2.3, 95% CI 1.3 to 4.1) and smoking (OR 4.5, 95% CI 2.5 to 7.9) were the only independent risk factors for young myocardial infarction. Furthermore, among patients who did not smoke, the polymorphism was associated with a nonsignificant increase in the risk of young myocardial infarction (OR 1.9, 95% CI 0.6 to 5.6); whereas, in the presence of smoking, the increase was statistically significant (OR 2.3, 95% CI 1.2 to 4.7). Smoking carriers of the thrombomodulin -33G/A polymorphism had a nearly 10-fold increased risk of young myocardial infarction (OR 9.8, 95% CI 4.3 to 22.4) when compared with nonsmoking non-carriers. We concluded that there was a significant association between the thrombomodulin -33G/A polymorphism and myocardial infarction in our population, especially in young patients. The clinical effect of this genetic factor was enhanced by smoking.

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PMID: 11848462


Other references

Bruder, P., 2002: Hubris and the undoing of American medicine. Hospital Topics 80(2): 35-37

Robinson, J.; Vastola, J.; Bookman, S., 2012: Doing more with less: applying lean methodology to EMS. Jems 37(3): 72-75

Lin, Teh Ping, 1963: Microinjection of the mouse ovum. Anat Rec 145(2): 254

Powell, L.W., 1954: Sarcoidosis of the myocardium. North Carolina Medical Journal 15(1): 28-32

van den Broek, J.C.; Verdam-de Witte, A., 2012: A man with a white macula. A man from the Dominican Republic presented with a white macula on the arm with sensibility loss. Skin biopsy showed a dermatitis with infiltration of dermal nerves. The diagnosis was indeterminate leprosy.

Yoshimoto, A.; Johdo, O.; Tone, H.; Okamoto, R.; Takeuchi, T., 1991: Photochemical production of anthracycline antibiotic oxaunomycin from precursor metabolite D788-1. Japanese Journal of Antibiotics 44(3): 264-268

Kruger,G.R.; Davis,V.M.; Weller,S.C.; Johnson,W.G., 2008: Response and survival of rosette-stage horseweed after exposure to 2,4-D. 2,4-D is often used as a preplant burndown herbicide to help control horseweed and other broadleaf weeds before planting in no-till corn and soyabean production. Isolated instances of poor horseweed control have occurred in production fields. The...

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Odegaard, F.; Diserud, O.H.; Engen, S.; Aagaard, K., 2000: The magnitude of local host specificity for phytophagous insects and its implications for estimates of global species richness. A new method for predicting host specificity for phytophagous insects at a local scale is presented. The method is based on the concept of effective specialization. Host specificity values for adult phytophagous beetles in a tropical dry forest in...

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