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Synthesis of some thiazolo(3,2-b)-1,2,4-triazole-5(6H)-ones and their novel Michael addition products with anti-inflammatory activities


, : Synthesis of some thiazolo(3,2-b)-1,2,4-triazole-5(6H)-ones and their novel Michael addition products with anti-inflammatory activities. Arzneimittel Forschung 51(6): 470-477

In this study, 21 new compounds having 2-methyl-6-benzylidenethiazolo(3,2-b)-1,2,4-triazol-5(6H)-one (2-4) and 2-methyl-6-(alpha-aminobenzyl)thiazolo(3,2-b)-1,2,4-triazole-5-ol (2a-4g) structures were synthesized. The structures of the compounds were proved by spectral and elemental analysis. All of the compounds synthesized were tested for their anti-inflammatory activity and ulcerogenic potential in mice at 10, 20 and 40 mg/kg dose levels.

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