+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Synthesis of some thiazolo(3,2-b)-1,2,4-triazole-5(6H)-ones and their novel Michael addition products with anti-inflammatory activities

, : Synthesis of some thiazolo(3,2-b)-1,2,4-triazole-5(6H)-ones and their novel Michael addition products with anti-inflammatory activities. Arzneimittel Forschung 51(6): 470-477

In this study, 21 new compounds having 2-methyl-6-benzylidenethiazolo(3,2-b)-1,2,4-triazol-5(6H)-one (2-4) and 2-methyl-6-(alpha-aminobenzyl)thiazolo(3,2-b)-1,2,4-triazole-5-ol (2a-4g) structures were synthesized. The structures of the compounds were proved by spectral and elemental analysis. All of the compounds synthesized were tested for their anti-inflammatory activity and ulcerogenic potential in mice at 10, 20 and 40 mg/kg dose levels.


Other references

Stock, J.A.; Kaplan, G.W., 1995: Ketoconazole for prevention of postoperative penile erection. To determine if ketoconazole, an inhibitor of testosterone synthesis, can prevent postoperative spontaneous erections in patients undergoing penile surgery. Ketoconazole was administered to 8 patients, aged 14 to 42 years, who underwent penile sur...

Kazanchyan P.P.; Oganesyan S.S.; Arutyunyan E.B., 1972: Preliminary results of the investigations of present-day local vertical movements of the Earth's crust in the area of the Zangezur earthquake epicenter, Armenia. Changes in radioactivity caused by migration of radioactive solutions, concentration of solutions depending on the stress distribution in a given zone; correlation between vertical movements, gravity force, and radioactivity plotted against earthq...

Simpson, S.A.; Harper, P.S., 2001: Prenatal testing for Huntington's disease: experience within the UK 1994-1998. Journal of Medical Genetics 38(5): 333-335

Franko, A.; Dodič-Fikfak, M.; Arnerić, N.; Dolžan, V., 2011: Inducible nitric oxide synthase genetic polymorphism and risk of asbestosis. Asbestos, a known occupational pollutant, may upregulate the activity of inducible nitric oxide synthase (iNOS) and thus the production of nitric oxide (NO). This study investigated whether iNOS (CCTTT)(n) polymorphism is associated with an incr...

Gozes, I.; Sragovich, S.; Schirer, Y.; Idan-Feldman, A., 2016: D-SAL and NAP: Two Peptides Sharing a SIP Domain. NAPVSIPQ (NAP) and all D-amino acid SALLRSIPA (D-SAL) are neuroprotective peptides derived from activity-dependent neuroprotective protein (ADNP) and activity-dependent neurotrophic factor (ADNF), respectively. Both proteins were shown to protect...

D.F.aipont, F.; L.M.igne, G.; Defaye, G.; E.A.ifi, M.; Berger, F.; Houlgatte, R.; Gicquel, C.; Plouin, P.F.; Bertagna, X.; Chabre, O.; Feige, J.J., 2003: Transcription profiling of benign and malignant adrenal tumors by cDNA macro-array analysis. Endocrine Research 28(4): 785-786

Doerell, E.G., 1927: Contributions to the problem of the control of yellow rust. L Observations on the yellow rust problem and on the control of yellow rust by fertilization. The writer summarizes and briefly comments upon some of the more important contributions to the problem of yellow rust of wheat (Puccinia glumarum). The disease is stated to have been very severe of recent years in Czecho-Slovakia, especially in t...

Miyake, M.; Saito, M.; Okudaira, M., 1964: Symposium On Intrahepatic Microcirculation: Methods For The Study Of Intra- Or Extra-Lobular Circulation; Hemodynamic And Morphological Aspects. 4. Studies On Intrahepatic Vascular Alterations In Cirrhosis Of The Liver. Japanese Circulation Journal 28: 33-39

Einum, P.; Kiupel, M.; Bolin, C., 2003: An outbreak of fowl cholera in ring-necked pheasants (Phasianus colchicus). A total of 120 ring-necked pheasants from a 3000-bird flock in Zeeland, MI, died over a 3-day period. Clinical signs included sudden death, diarrhea, and limping. At necropsy, hepatomegaly with multifocal cream-colored foci randomly distributed th...

Bell, R.M.; Pennington, J.A.T.Reviewer, 1990: Holy anorexia (book review). Journal of the American Dietetic Association 90: 4