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The antioxidant status during maturation of reticulocytes to erythrocytes in type 2 diabetics


, : The antioxidant status during maturation of reticulocytes to erythrocytes in type 2 diabetics. Free Radical Biology & Medicine 35(2): 133-139, July 15

Free radical-induced lipid peroxidation has been associated with numerous disease processes including diabetes mellitus. The extent of lipid peroxidation (LPO) and antioxidant defense system (i.e., levels of glutathione (GSH), glucose-6-phosphate dehydrogenase (G6PDH), glutathione reductase (GR), glutathione peroxidase (GPx), glutathione-S-transferase (GST), and catalase (CAT)) were evaluated in reticulocytes and erythrocytes of type 2 diabetic males and age-matched controls. Type 2 diabetics have shown increased lipid peroxidation and decreased levels of GSH, GR, GPx, G6PDH, and GST both in reticulocytes and erythrocytes compared to controls, indicating the presence of oxidative stress and defective antioxidant systems in these patients. CAT activity is found to be enhanced in both the reticulocytes and erythrocytes of diabetics, with a greater percentage enhancement in reticulocytes. The extent of increase in lipid peroxidation is greater in erythrocytes compared to reticulocytes in these patients. Furthermore, the maturation of reticulocytes to erythrocytes resulted in decreased GSH and decreased activities of all antioxidant enzymes (except CAT) both in normals and type 2 diabetes individuals, indicating decreased scavenging capacity as reticulocytes mature to erythrocytes. These maturational alterations are further intensified in type 2 diabetics. The present study reveals that the alterations in lipid peroxidation and antioxidant system lean toward early senescence of erythrocytes in type 2 diabetic patients.

US$19.90

PMID: 12853069

DOI: 10.1016/s0891-5849(03)00071-6


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Sims, J.T.; Ganguly, S.; Fiore, L.S.; Holler, C.J.; Park, E-Sil.; Plattner, R., 2009: STI571 sensitizes breast cancer cells to 5-fluorouracil, cisplatin and camptothecin in a cell type-specific manner. Previously, we demonstrated that Abl kinases are highly active in invasive breast cancer cell lines, and contribute to survival in response to nutrient deprivation, invasion and proliferation. To determine whether an Abl kinase inhibitor, STI571 (...

Medan D.; Hilger H.H., 1992: Comparative flower and fruit morphogenesis in colubrina rhamnaceae with special reference to colubrina asiatica. Flower and fruit morphogenesis of Colubrina asiatica, including aspects of fruit dehiscence and seed morphology, were studied by scanning electron microscopy and serial sectioning. Material from 13 additional species representing most intrageneric...

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Schwenk, F.W., 1980: Callus formation from mechanically isolated soybean glycine max cultivar columbus cotyledonary cells. Cells mechanically isolated in sterile, distilled water from cotyledons of 5 day old soybeans enlarged and divided within 3 days on modified Schenk-Hildebrandt's S-H medium. Callus developed and grew on the same medium. Cell growth and initia...

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Gibson C.M.; Stone P.H.; Pasternak R.C.; Sandor T.; Sacks F.M., 1990: Sample size requirements to assess atherosclerosis regression using quantitative angiography. Circulation 82(4 SUPPL 3): III517

Koyama, M.; Hill, G.R., 2016: Recent insights to the mechanisms of graft-versus-host disease. NlmCategory="UNASSIGNED">Allogeneic hematopoietic stem cell transplantation remains the cornerstone of curative therapy for haematological malignancies but is limited by graft-versus-host disease (GVHD), both acute and chronic. Exciti...

Soth, L., 1985: Farmers and their world market. Proposed 1985 farm bill changes: taking the bias out of farm policy: symposium proceedings March 1985 Washington DC: 4

Harris, A., 2006: Gender in linear and nonlinear history. In response to Helen Gediman's notion of premodern, modern, and postmodern eras in the study of gender, an argument is made for a non-linear approach to this history and for situating it in the context of other historical developments-social,...

Chiang R.G.; Govind C.K., 1986: Reorganization of synaptic ultrastructure at facilitated lobster neuromuscular terminals. Prolonged stimulation of the single excitor axon to the lobster distal accessory flexor muscle in the presence of ouabain caused long-term facilitation at its neuromuscular synapses. Hence the extracellularly recorded synaptic potentials failed le...