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The antiviral drug docosanol as a treatment for Kaposi's sarcoma lesions in HIV type 1-infected patients: a pilot clinical study


, : The antiviral drug docosanol as a treatment for Kaposi's sarcoma lesions in HIV type 1-infected patients: a pilot clinical study. Aids Research and Human Retroviruses 17(1): 35-43

Docosanol inhibits a broad spectrum of lipid-enveloped viruses in vitro including HSV-1, HSV-2, VZV, CMV, HHV-6, and HIV-1. These observations led us to conduct a pilot clinical study with docosanol 10% cream as a topical treatment for Kaposi's sarcoma (KS) in HIV-1-infected patients. In this open-label study 28 cutaneous KS lesions in 10 HIV-1-infected patients were treated topically five times daily for 4 weeks with evaluation of lesion characteristics of area, edema, and color. All patients elected to enroll in an extended treatment protocol and continued to treat for up to 35 weeks. Within 28 days, 2 of 10 patients exhibited a partial response based on standardized criteria exhibiting 74 to 83% reductions in total target lesion areas. With extended treatment, a partial response was exhibited in two additional patients where total target lesion area was reduced by 52% in one patient and target lesions in another patient that had been large, swollen, and painful at study initiation were no longer visible. No patient experienced disease progression or signs of visceral disease. The average percent decrease in lesion area for all target lesions was 20% (p < 0.01). A patient's response to therapy appeared to be independent of anti-HIV regimen, HIV viral load, or previous KS treatments. These results suggest that docosanol merits further investigation as a potential topical therapy in the treatment of AIDS-associated Kaposi's sarcoma lesions.

US$19.90

PMID: 11177381

DOI: 10.1089/088922201750056762


Other references

Rak, T., 1992: Productivity of sows and rearing of boars. Three groups, each of 18 boars of the Poltava type of the Soviet Meat (SM) breed, were treated as follows during rearing: (1) given forced exercise for 2 km over a 1-h period; (2) reared on free range; (3) reared in pens, without forced exercise....

Saitoh, H.; Kawai, S.; Iseki, K.; Miyazaki, K.; Arita, T., 1988: Binding of organic cations to brush border membrane from rat small intestine. The binding of six organic cations (chlorpromazine, promethazine, imipramine, diphenhydramine, methochlorpromazine and propantheline) to the brush border membrane isolated from rat small intestine has been investigated. The cations were bound to t...

Tang, Z.K.; Zhai, J.P.; Tong, Y.Y.; Hu, X.J.; Saito, R.; Feng, Y.J.; Sheng, P., 2008: Resonant Raman scattering of the smallest single-walled carbon nanotubes. We report optical properties of the smallest single-walled carbon nanotubes (SWNTs) with a diameter of only 3 A. These ultrasmall SWNTs are fabricated in the elliptical nanochannels of an AlPO-11 (AEL) single crystal. Polarized and resonant Raman...

Levich V.G.; Krylov V.S., 1969: Surface tension driven phenomena. Sears, William R (Editor) Annual Review Of Fluid Mechanics Vol 1 Vii + 459p Illus Annual Reviews, Inc : Palo Alto, Calif , U S A 293-316

Allard B.; Haakansson K.; Karlsson S., 1987: The importance of sorption phenomena in relation to trace element speciation and mobility. Lecture Notes in Earth Sciences 11: 99-112

Fleming, J.R., 1994: What in the world is being done about TBAs? An overview of international and national attitudes to traditional birth attendants. Many of the half million women per year who die in childbirth are attended by traditional birth attendants (TBAs). Whether they fare better when such an attendant is trained remains uncertain; even the World Health Organization seems to have tempe...

Bishop, B.E.; Doggrell, S.A., 1994: The effects of racemic cromakalim, BRL 38226 and levcromakalim on the membrane potential of the rat aorta and of BRL 38226 on the contractile activity of the rat aorta and portal vein. 1. The effects of racemic cromakalim and the (+)-3R,4S and (-)-3S,4R isomers, BRL 38226 and levcromakalim respectively, on the membrane potential of the rat aorta have been determined. In addition, preliminary studies of the effects of BRL 38226 o...

Caballero, C.; Jantus-Lewintre, E.; Carrato, A.; García-Foncillas, J.; Gascón, P.; Blasco, A.; Moreno-Nogueira, J.A.; Guillem, V.; López, R.; Codes, M.; Antón, A.; Díaz-Rubio, E.; Camps, C., 2015: Oncological translational research in the Spanish national health system: the INTRO study. Under the auspices of the Foundation for Excellence and Quality in Oncology (ECO), the Translational Research in Oncology Medical Services Study (INTRO) was conducted with the aim of describing the current state of, and future expectations for t...

Delvaux M.; Botella A.; Fioramonti J.; Frexinos J.; Bueno L., 1991: Galanin induced contraction of isolated cells from circular muscle layer of pig ileum. The effects of galanin and its interaction with cholecystokinin and acetylcholine on smooth muscle cells were studied in vitro on isolated cells obtained from pig ileum circular muscle layer. Galanin induced a concentration-dependent cell contract...

Lanier, W.L., 2010: The physiognomy of Mayo Clinic Proceedings, 2010. Mayo Clinic Proceedings 85(1): 15-17