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The complete sequence of hepatitis E virus genotype 4 reveals an alternative strategy for translation of open reading frames 2 and 3


, : The complete sequence of hepatitis E virus genotype 4 reveals an alternative strategy for translation of open reading frames 2 and 3. Journal of General Virology 81(Pt 7): 1675-1686

Isolates of hepatitis E virus (HEV) have recently been described from China that are distinct from Burmese, Mexican and US viruses and constitute a novel genotype (genotype 4). Here, the complete genomic sequence of a representative isolate of genotype 4 HEV, amplified directly from the stool of an acutely infected patient, is presented. Analysis of the entire sequence confirms our previous conclusion, based upon partial sequence data, that these Chinese isolates belong to a novel genotype. Typical of genetic variation in HEV, most nucleotide substitutions occur in the third base of the codon and do not affect the amino acid sequence. The genotype 4 virus is unusual in that a single nucleotide insertion in the ORF 3 region changes the initiation of ORF 3, and perhaps also ORF 2. The consequences of these changes are discussed.

US$19.90

PMID: 10859372

DOI: 10.1099/0022-1317-81-7-1675


Other references

Kulpati, D.D.; Singh, H.; Singhal, V.S.; Misra, R.C., 1983: Non-malignant H-type tracheo-esophageal fistula in a young girl. Indian Journal of Chest Diseases & Allied Sciences 25: 76-78

Judge Alan; Burgess Margo; LaFleche Paul, 1987: Permafrost investigations at the Illisarvik experimental drained lake site, Canadian western Arctic. Congress of the International Union for Quaternary Research Pages 196

Yoshino Fumio; Tago Hidenori; Hosoya Nobuo, 1987: Evaluation of infiltration facilities of rainfall at Yatabe experimental field of groundwater. Journal of Groundwater Hydrology 29(1): 27-39

Samhammer, E., 1972: Contribution to the knowledge of ready made foods. Ernahrungs Umschau: 19 (5) 163-165

Davies, D.P., 1990: Growth hormone deficiency in children with chromosomal abnormalities. Archives of Disease in Childhood 65(10): 1183-1183

Zhang, Z.; Zhang, Y.; Wang, W.; Huang, R.X.n, 2013: Universal structure of mesoscale eddies in the ocean. Mesoscale eddies dominate oceanic kinetic energy at sub-initial frequencies. Their three-dimensional structure has, however, remained obscure, hindering better understanding of eddy dynamics. Here by applying the composite analysis of satellite al...

Carlsen, B., 2003: General practitioners' experiences with the list patient system. Tidsskrift for den Norske Laegeforening 123(10): 1322-1324

Kong, X.; Yu, Z., 2002: Studies on the karyotypes of two species of sea bream and six species of flatfishes. Aquaculture 204(3-4): 222-223, 11 February

Stone, O.J.; Westburg, S.P., 1974: Superficial fungus infections. American Family Physician 9(1): 163-172

Morrisey, J.L.; Shihabi, Z.K., 1979: Assay of urinary 4-hdyroxy-3-methoxymandelic (vanillylmandelic) acid by liquid chromatography with electrochemical detection. We describe a method for the assay of urinary 4-hydroxy-3-methoxymandelic acid (vanillylmandelic acid) based on separation on a microparticulate reversed-phase column and direct electrochemical detection. The method can be used after extraction fr...